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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >In vitro and in?vivo biocompatibility study of polyacrylate TiO 2 @Ag coated nanoparticles for the radiation dose enhancement
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In vitro and in?vivo biocompatibility study of polyacrylate TiO 2 @Ag coated nanoparticles for the radiation dose enhancement

机译：体外和体内的聚丙烯酸酯TiO 2的生物相容性研究，用于辐射剂量增强的植物纳米粒子

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To enhance the efficacy of radiation therapy, functionalised core-shell nanoparticles (CS NPs) are used as a radiosensitizer. These NPs can act as a therapeutic agent and carrier for other therapeutic agents. In this study, the first poly-acrylic acid modified silver-coated titanium dioxide NPs were fabricated to evaluate the radiation dose enhancement within the human tissue equivalent polymer gel after investigating the biocompatibility. Macrophage cell line and rats model were used for in?vitro and in?vivo study respectively. Two different beam qualities were applied to quantify the radiation dose enhancement with different concentrations of NPs in the polymer gel. The dose enhancement factors (DEFs) indicated that these biocompatible CS NPs are more effective for the radiation dose enhancement at low energy x-rays (80?kV) as compared to the high energy gamma (1.25?MeV Co 60 ). These results suggested that functionalised core-shell silver-coated titanium dioxide NPs have great potential as a radiosensitizer in radiation therapy.
机译：为了增强放射治疗的功效，用作官能化的核 - 壳纳米颗粒（CS NPS）用作辐射敏化剂。这些NPS可以作为其他治疗剂的治疗剂和载体。在该研究中，制备第一聚丙烯酸改性的银涂覆的二氧化钛NP，以在研究生物相容性后评估人组织当量聚合物凝胶中的辐射剂量增强。巨噬细胞系和大鼠模型分别用于体外和体内研究。施用两种不同的光束质量以在聚合物凝胶中用不同浓度的NPS量化辐射剂量增强。剂量增强因子（DEFS）表明，与高能γ（1.25〜MEV CO 60）相比，这些生物相容性CS NP对低能量X射线（80 kV）的辐射剂量增强更有效。这些结果表明，官能化芯壳银涂层二氧化钛NPS具有放射性敏感剂的极大潜力。

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