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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >TiO2 nanotubes regulate histone acetylation through F-actin to induce the osteogenic differentiation of BMSCs
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TiO2 nanotubes regulate histone acetylation through F-actin to induce the osteogenic differentiation of BMSCs

机译：TiO2纳米管通过F-Actin调节组蛋白乙酰化，诱导BMSCs的骨质发生分化

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摘要

Bone integration on the surface of titanium prosthesis is critical to the success of implant surgery. Good Bone integration at the contact interface is the basis of long-term stability. TiO2 nanotubes have become one of the most commonly used modification techniques for artificial joint prostheses and bone defect implants due to their good biocompatibility, mechanical properties and chemical stability. TiO2 nanotubes can promote F-actin polymerization in bone mesenchymal stem cells (BMSCs) and osteogenic differentiation. The possibility of F-actin as an upstream part to regulate GCN5 initiation of osteogenesis was discussed. The results of gene loss and functional acquisition assay, immunoblotting assay and fluorescence staining assay showed that TiO2 nanotubes could promote the differentiation of BMSCs into osteoblasts. The intervention of TiO2 nanotubes can make BMSCs form stronger F-actin fibre bundles, which can drive the differentiation process of osteogenesis. Our results showed that F-actin mediated nanotube-induced cell differentiation through promoting the expression of GCN5 and enhancing the function of GCN5 and GCN5 was a key regulator of the osteogenic differentiation of BMSCs induced by TiO2 nanotubes as a downstream mediated osteogenesis of F-actin, providing a novel insight into the study of osteogenic differentiation on surface of TiO2 nanotubes.
机译：钛假体表面上的骨融合对于植入手术的成功至关重要。接触界面处的良好骨骼集成是长期稳定性的基础。由于它们的良好的生物相容性，机械性能和化学稳定性，TiO2纳米管成为人工关节假体和骨缺损植入物中最常用的改性技术之一。 TiO2纳米管可以促进骨间充质干细胞（BMSCs）和骨质发生分化中的F-肌动蛋白聚合。讨论了F-Actin作为调节GCN5的上游部分的可能性进行了探讨。基因损失和功能采集测定的结果，免疫印迹测定和荧光染色测定结果表明，TiO2纳米管可以促进BMSCs进入成骨细胞的分化。 TiO2纳米管的干预可以使BMSCs形成更强的F-肌动蛋白纤维束，其可以驱动骨肉发生的分化过程。我们的结果表明，通过促进GCN5的表达和增强GCN5和GCN5的功能的F-actin介导的纳米管诱导的细胞分化是TiO2纳米管作为F-Actin的下游介导的骨质发生的BMSCs的骨开发分化的关键调节器，提供了对TiO2纳米管表面骨质化分化研究的新颖洞察。

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