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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Determination of Diclofenac Sodium in Pharmaceutical Sample Using Copper Nanoparticles/Reduced Graphene Oxide Modified Glassy Carbon Electrode
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Electrochemical Determination of Diclofenac Sodium in Pharmaceutical Sample Using Copper Nanoparticles/Reduced Graphene Oxide Modified Glassy Carbon Electrode

机译：使用铜纳米粒子/氧化石墨烯改性玻碳电极的药物样品中双氯芬酸钠的电化学测定

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摘要

This study presents electrochemical determination of diclofenac sodium (DCS) in a pharmaceutical sample using copper nanoparticles reduced graphene oxide hybrid electrodes (Cu NPs/rGO). rGOnanosheets were synthesized on a glassy carbon electrode (GCE) by modified Hummers method, and then, Cu NPs were electrodeposited on rGO/GCE. Results of structure and morphology studies by SEM and XRD revealed that the irregular Cu NPs electrodeposited in crystal structure with approximately 130nm diameter. Electrochemical analyses using the CV technique showed that Cu NPs/rGO/GCE exhibited a higher sensitivity for determination of DCS than that GCE, rGO/GCE and Cu NPs/GCE due to synergetic effect of Cu NPs and rGO which facilitates the electron transfer between the electrode and the electroactive species in solution and improve electrocatalytic oxidation of DCS. Amperometry measurements on Cu NPs/rGO/GCE as DCS sensor showed that linear range, limit of detection and sensitivity were obtained 20 to 400 μM, 8nM and 0.0356μA/μM, respectively. The applicability of Cu NPs/rGO/GCE to determine DCS concentration in the prepared real pharmaceutical sample was examined and results showed that recovery (≥97.66%) and RSD (≤3.05%) values were acceptable and this method provided suitable precision and accuracy for practical analyses in the pharmaceutical samples using Cu NPs/rGO/GCE.
机译：本研究介绍了使用铜纳米颗粒还原氧化物杂交电极（Cu NPS / Rgo）的药物样品中双氯芬太钠（DCS）的电化学测定。通过改性的悍马方法在玻璃碳电极（GCE）上合成RgonanosheCer，然后在RGO / GCE上电沉积Cu NPS。 SEM和XRD结构和形态学研究结果显示，在晶体结构中电沉积的不规则Cu NP，直径约为130nm。使用CV技术的电化学分析显示Cu NPS / RGO / GCE对测定DC的敏感性比Cu NP和Rgo的协同作用导致的GCE，RGO / GCE和Cu NPS / GCE，这有助于所述电子转移电极和溶液中的电活性物种，改善DCS电催化氧化。作为DCS传感器的Cu NPS / RGO / GCE上的安培测量测量结果显示，在20至400μm，8nm和0.0356μA/μm的线性范围内，检测和灵敏度分别为400μm。检查Cu NPS / Rgo / GCE在制备的真正药物样品中确定DCS浓度的适用性，结果表明，恢复（≥97.66％）和RSD（≤3.05％）值是可接受的，并且该方法提供了适当的精度和精度使用Cu NPS / RGO / GCE在药物样品中的实际分析。

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