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首页> 外文期刊>International Journal of Medical Sciences >Cardiac Troponin I association with critical illness and death risk in 726 seriously ill COVID-19 patients: A retrospective cohort study
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Cardiac Troponin I association with critical illness and death risk in 726 seriously ill COVID-19 patients: A retrospective cohort study

机译：心肌肌钙蛋白I联合与危重疾病和死亡风险726重视患病患者：一项回顾性队列研究

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Background: For coronavirus disease 2019 (COVID-19), early identification of patients with serious symptoms at risk of critical illness and death is important for personalized treatment and balancing medical resources. Methods: Demographics, clinical characteristics, and laboratory tests data from 726 patients with serious COVID-19 at Tongji Hospital (Wuhan, China) were analyzed. Patients were classified into critical group (n = 174) and severe group (n= 552), the critical group was sub-divided into survivors (n = 47) and non-survivors (n = 127). Results: Multivariable analyses revealed the risk factors associated with critical illness in serious patients were: Advanced age, high respiratory rate (RR), high lactate dehydrogenase (LDH) level, high hypersensitive cardiac troponin I (hs-cTnI) level, and thrombocytopenia on admission. High hs-cTnI level was the independent risk factor of mortality among critically ill patients in the unadjusted and adjusted models. ROC curves demonstrated that hs-cTnI and LDH were predictive factors for critical illness in patients with serious COVID-19 whereas procalcitonin and D-Dimer with hs-cTnI and LDH were predictive parameters in mortality risk. Conclusions: Advanced age, high RR, LDH, hs-cTnI, and thrombocytopenia, constitute risk factors for critical illness among patients with serious COVID-19, and the hs-cTnI level helps predict fatal outcomes in critically ill patients.? The author(s).
机译：背景：对于冠状病毒疾病2019（Covid-19），早期鉴定严重症状的患者，危险疾病的危险性和死亡风险对于个性化治疗和平衡医疗资源非常重要。方法：分析了人口统计数据，临床特征和实验室检验726名严重Covid-19患者在同济医院（武汉）的患者中的数据进行了分析。患者分为关键群（n = 174）和严重组（n = 552），将临界基团分为幸存者（n = 47）和非幸存者（n = 127）。结果：多变量分析揭示了与严重患者危重疾病相关的危险因素是：晚期，高呼吸率（RR），高乳酸脱氢酶（LDH）水平，高过敏心肌肌钙蛋白I（HS-CTNI）水平，以及血小板减少症入学。高HS-CTNI水平是未经调整和调整模型中危重病人的严重病患者中死亡率的独立风险因素。 ROC曲线证明HS-CTNI和LDH是严重Covid-19患者危重疾病的预测因素，而HS-CTNI和LDH的ProCalcitonin和D-二聚体是死亡率风险的预测参数。结论：晚期，高RR，LDH，HS-CTNI和血小板减少症，构成严重Covid-19患者危重疾病的危险因素，HS-CTNI水平有助于预测患者患者的致命结果。作者。

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