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首页> 外文期刊>Epigenetics & Chromatin >Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms
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Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms

机译：跨国跨越王国真核传奇共同综合体综合体的保护与多样性

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The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone modifications, and interactions with transcription factors. Multiple lines of evidence indicate the existence of distinct variants of SAGA among organisms as well as within a species, permitting diverse functions to dynamically regulate cellular pathways. Our co-expression analysis of genes encoding human SAGA components showed enrichment in reproductive organs, brain tissues and the skeletal muscle, which corresponds to their established roles in developmental programs, emerging roles in neurodegenerative diseases, and understudied functions in specific cell types. SAGA subunits modulate growth, development and response to various stresses from yeast to plants and metazoans. In metazoans, SAGA further participates in the regulation of differentiation and maturation of both innate and adaptive immune cells, and is associated with initiation and progression of diseases including a broad range of cancers. The evolutionary conservation of SAGA highlights its indispensable role in eukaryotic life, thus deciphering the mechanisms of action of SAGA is key to understanding fundamental biological processes throughout evolution. To illuminate the diversity and conservation of this essential complex, here we discuss variations in composition, essentiality and co-expression of component genes, and its prominent functions across Fungi, Plantae and Animalia kingdoms.
机译：佐贺络合物是一种进化保守的转录共同诱导剂，其通过其组蛋白乙酰转移酶和耐脂肪酶活性，特异性组蛋白修饰的识别和与转录因子的相互作用来调节基因表达。多条证据表明生物体中的佐贺和物种内的不同变体的存在，允许各种功能动态调节细胞途径。我们对编码人类传奇组分的基因的共同表达分析表明生殖器官，脑组织和骨骼肌中的富集，这对应于其在发育计划中的成熟作用，新兴疾病的源于神经变性疾病的作用，以及特定细胞类型的核心功能。 SAGA亚基调节生长，发展和对来自酵母和植物和美唑烷的各种压力的反应。在美唑诺斯，传奇进一步参与了先天和自适应免疫细胞的分化和成熟，与包括广泛癌症的疾病的开始和进展相关。 Saga的进化节约凸显了其在真核生物生活中的不可或缺的作用，从而解读了传奇的行动机制是了解整个进化中的基本生物过程的关键。为了照亮这种基本综合体的多样性和保护，在这里我们讨论了组成，基本性和组分基因的共同表达的变化，以及跨真菌，植物和动物王国的突出功能。

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