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首页> 外文期刊>Experimental and clinical transplantation >Systemic Complement Activation in Donation After Brain Death Versus Donation After Circulatory Death Organ Donors
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Systemic Complement Activation in Donation After Brain Death Versus Donation After Circulatory Death Organ Donors

机译：循环死亡器官供体后脑死后捐赠捐赠的全身补充活化

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Objectives: Complement activation in organs from deceased donors is associated with allograft injury and acute rejection. Because use of organs from donors after circulatory death is increasing, we characterized relative levels of complement activation in organs from donors after brain death and after circulatory death and examined associations between donor complement factor levels and outcomes after kidney and liver transplant. Materials and Methods: Serum samples from 65 donors (55 donations after brain death, 10 donations after circulatory death) were analyzed for classical, lectin, alternative, and terminal pathway components by Luminex multiplex assays. Complement factor levels were compared between groups, and associations with posttransplant outcomes were explored. Results: Serum levels of the downstream complement activation product C5a were similar in organs from donors after circulatory death versus donors after brain death. In organs from donors after circulatory death, complement activation occurred primarily via the alternative pathway; the classical, lectin, and alternative pathways all contributed in organs from donors after brain death. Donor complement levels were not associated with outcomes after kidney transplant. Lower donor complement levels were associated with need for transfusion, reintervention, hospital readmission, and acute rejection after liver transplant. Conclusions: Complement activation occurs at similar levels in organs donated from donors after circulatory death versus those after brain death. Lower donor complement levels may contribute to adverse outcomes after liver transplant. Further study is warranted to better understand how donor complement activation contributes to posttransplant outcomes.
机译：目的：死者供体中的器官中的补充激活与同种异体移植损伤和急性排斥有关。由于在循环死亡之后使用供体的器官正在增加，因此我们在脑死后的供体和肾脏和肝脏移植后的循环死亡和循环死亡与结果的循环死亡和循环之间的关联后表现了来自捐献者的相对水平的相对水平。材料和方法：通过Luminex多重测定分析了来自65名供体的65个供体的样品（55次捐赠后，循环死亡后的捐赠10次捐赠）。在组之间比较补体因子水平，探讨了与后翻境结果的关联。结果：在脑死后循环死亡与供体后，来自供体的血清中下游补体激活产品C5a的血清水平在血液死亡之后。在循环死亡后从供体的器官中，通过替代途径，相互激活主要发生;古典，凝集素和替代途径都在脑死后捐赠者的助理器官中贡献。供体补体水平与肾移植后的结果无关。降低供体补体水平与肝脏移植后需要输血，重新入住，医院入院和急性排斥症相关。结论：在循环死亡与脑死后，在供体中捐赠的器官中的相似水平发生补体激活。降低供体补体水平可能导致肝移植后的不利结果。有必要进一步研究以更好地了解供体补充激活如何促进普及普及的结果。

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