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Effects of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer

机译：益生菌对食管癌术后患者胃肠共产复杂和营养状况的影响

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BACKGROUND:Gastrointestinal complications and malnutrition are common problems that affect postoperative rehabilitation and survival of patients with esophageal cancer. Evidence has shown that probiotics have a positive effect on improving gastrointestinal complications and nutritional status of patients with esophageal cancer after surgery, but there is a lack of prospective studies on this topic. We designed this prospective randomized controlled trial to evaluate the effects of probiotics on gastrointestinal complications and nutritional status in patients with postoperative esophageal cancer.METHODS:This is a prospective, randomized, double-blind, placebo-controlled trial. It was approved by the Clinical Research Ethics Committee of our hospital. 192 patients will be randomly divided into probiotics group and the placebo group in a 1:1 ratio. After operation, probiotics and placebo will be given orally for 8?weeks. The indexes of nutritional status and incidence of digestive tract complications will be recorded and the data will be analyzed by SPSS 18.0 software.DISCUSSION:This study will evaluate the effect of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer. The results of this study will provide clinical basis for the use of probiotics in postoperative treatment of esophageal cancer.TRIAL REGISTRATION:OSF Registration number: D DOI 10.17605/OSF.IO/QHW86.Copyright ? 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
机译：背景：胃肠道并发症和营养不良是影响食管癌患者术后康复和存活的常见问题。证据表明，益生菌对手术后改善食管癌患者的胃肠并发症和营养状况有积极影响，但缺乏对这一主题的前瞻性研究。我们设计了该预期随机对照试验，以评估益生菌对术后食管癌患者胃肠共产症和营养状况的影响。方法：这是一项前瞻性，随机，双盲，安慰剂对照试验。它被我们医院的临床研究伦理委员会批准。 192例患者将随机分为益生菌组和安慰剂组1：1的比例。操作后，益生菌和安慰剂将口服给予8？周。将记录营养状况和消化道并发症发病率的指标，并通过SPSS 18.0软件分析数据。该研究将评估益生菌对食管癌术后患者胃肠道并发症和营养状况的影响。本研究的结果将为食管癌术后治疗提供益生菌的临床基础.Trial注册：OSF注册号：D DOI 10.17605 / OSF.IO / QHW86.Copyright？ 2021提交人。由Wolters Kluwer Health，Inc。出版

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