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Development of molecular tools for diagnosis of Alzheimer’s disease that are based on detection of amyloidogenic proteins

机译：基于淀粉样蛋白蛋白质的阿尔茨海默病诊断分子工具的发展

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摘要

Alzheimer’s disease (AD) is the most common form of dementia that usually occurs among older people. AD results from neuronal degeneration that leads to the cognitive impairment and death. AD is incurable, typically develops over the course of many years and is accompanied by a loss of functional autonomy, making a patient completely dependent on family members and/or healthcare workers. Critical features of AD are pathological polymerization of Aβ peptide and microtubule-associated protein tau, accompanied by alterations of their conformations and resulting in accumulation of cross-β fibrils (amyloids) in human brains. AD apparently progresses asymptomatically for years or even decades before the appearance of symptoms. Therefore, development of the early AD diagnosis at a pre-symptomatic stage is essential for potential therapies. This review is focused on current and potential molecular tools (including non-invasive methods) that are based on detection of amyloidogenic proteins and can be applicable to early diagnosis of AD.
机译：阿尔茨海默病（AD）是通常在老年人之间发生的最常见的痴呆形式。神经元变性的AD结果导致认知障碍和死亡。广告是不可市性的，通常在多年的过程中发展，并伴随着功能性自治的丧失，使患者完全依赖家庭成员和/或医疗保健工人。 AD的关键特征是Aβ肽和微管相关蛋白Tau的病理聚合，伴随着它们的构象的改变，并导致人脑中的横β原纤维（淀粉样蛋白）积累。广告显然在症状外观之前甚至几十年进展。因此，在前症状阶段的早期广告诊断的发展对于潜在的疗法至关重要。本综述专注于基于淀粉样蛋白的检测的电流和潜在的分子工具（包括非侵入性方法），并且可以适用于AD的早期诊断。

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