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首页> 外文期刊>Prion >Creutzfeldt–Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues
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Creutzfeldt–Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues

机译：妊娠中的克雷斯菲尔特 - 雅各布疾病：使用修饰的rt-quic来确定胎盘组织中的感染性

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摘要

Sporadic Creutzfeldt–Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we used sensitive real-time quaking-induced conversion (RT-QuIC) assays to test for the infectious prion protein (PrP Sc ) in products of gestation. A 35-year-old woman with sCJD presented in her 10 th gestational week with an eight month history of progressive cognitive impairment. During C-section, amniotic fluid, cord blood and placental tissue were collected and analysed using RT-QuIC protocols adapted for use with these tissues. The patient’s diagnosis of sCJD, MM2 subtype, was confirmed at autopsy. There were borderline positive results in one sampled area of the placenta, but otherwise the cord blood and amniotic fluid were negative on our RT-QuIC assays. A healthy baby was delivered via C-section at 36?weeks and 3?days gestational age, with no evidence of neurological disease to date. We conclude that precautions should be taken with products of gestation, but the level of PrP Sc is extremely low.
机译：Sporadic Creutzfeldt-Jakob疾病（SCJD）很少影响生育年龄的妇女。目前没有垂直传输的证据。鉴于在这些患者中进行剖腹产（C型）的生物安全影响，我们使用敏感的实时判断诱导的转化（RT-QUIC）测定来测试妊娠期产品中的传染朊病毒蛋白（PRP SC）。一名35岁的女性，SCJD介绍了她的第10个妊娠周，历史八个月的渐进认知障碍。在C段，使用适用于这些组织的RT-Quic方案来收集和分析羊水，脐带血和胎盘组织。患者对SCJD，MM2亚型的诊断在尸检时得到了确认。在胎盘的一个采样区域中存在邻接阳性结果，但否则脐带血和羊水对我们的RT-Quic测定是阴性的。一个健康的婴儿通过36？周和3个？天孕龄，没有迄今为止的神经疾病的证据。我们得出结论，应采取预防措施与妊娠的产品，但PRP SC的水平极低。

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