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首页> 外文期刊>Thoracic cancer. >miR‐493 by regulating of c‐Jun targets Wnt5a/PD‐L1‐inducing esophageal cancer cell development
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miR‐493 by regulating of c‐Jun targets Wnt5a/PD‐L1‐inducing esophageal cancer cell development

机译：MiR-493通过调节C-Jun靶WNT5A / PD-L1诱导食管癌细胞发育

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Background Esophageal cancer is one of the most common cancers across the globe; the 5‐year survival of esophageal cancer patients is still low. MicroRNA (miRNA) dysregulation has been implicated in cancer development, and the miRNAs play a pivotal role in esophageal cancer pathogenesis. It is urgently needed to find out how miRNA dysregulation was involved in esophageal cancer (EC) development. Methods Through experiments in vivo and in vitro, we explored potential signaling pathways, miR‐493/Wnt5A/c‐JUN loop, in EC. Their mechanistic roles in EC cell proliferation, migration, and invasion were investigated through multiple validation steps in EC9706 and TE13 cell lines and EC specimens. Results Overexpression of miR‐493 attenuates esophageal cancer cell proliferation, migration, and invasion in vivo and in vitro. Moreover, miR‐493 downregulation is an unfavorable factor in EC and negatively correlated with Wnt5A. The existence of miR‐493 is also an important attribute of metabolism. Based on mechanism analyses, we show that miR‐493 inhibits the activity of c‐JUN and p‐PI3K/p‐AKT with enhanced p21 and directly regulates Wnt5A expression and function, whereas c‐JUN binds the promoter region of miR‐493 and suppressed the expression of miR‐493, forming a negative feedback loop. Conclusions The miR‐493/Wnt5A/c‐JUN loop is a molecular feedback loop that refers to the development of esophageal cancer cells and a potential target for the treatment of esophageal cancer.
机译：背景食管癌是全球最常见的癌症之一;食管癌患者的5年生存率仍然很低。 MicroRNA（miRNA）失呼综合理涉及癌症发育，MiRNA在食管癌发病机制中发挥枢轴作用。迫切需要了解如何参与食管癌（EC）发展的miRNA失调如何。方法通过体内和体外实验，我们探讨了EC中的潜在信令途径，MIR-493 / WNT5A / C-Jun环路。通过EC9706和TE13细胞系和EC标本的多种验证步骤研究了EC细胞增殖，迁移和侵袭的机械作用。结果MIR-493的过表达衰减体内和体外食管癌细胞增殖，迁移和侵袭。此外，MiR-493下调是EC中不利的因素，与WNT5A负相关。 miR-493的存在也是新陈代谢的重要属性。基于机制分析，我们表明miR-493抑制了C-Jun和P-Pi3k / p-akt的活性，具有增强的P21，直接调节Wnt5a表达和功能，而C-Jun结合MiR-493的启动子区和抑制miR-493的表达，形成负反馈回路。结论MIR-493 / WNT5A / C-JUN环是一种分子反馈回路，其是指食管癌细胞的发育和治疗食管癌的潜在目标。

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