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首页> 外文期刊>Dermatology and Therapy >Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation
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Cold Atmospheric Plasma (CAP) for the Treatment of Actinic Keratosis and Skin Field Cancerization: Clinical and High-Frequency Ultrasound Evaluation

机译：冷大气血浆（帽）用于治疗光化角质症和皮肤场癌症：临床和高频超声评估

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IntroductionCold atmospheric plasma (CAP) has been clinically demonstrated to be an effective treatment for actinic keratosis (AK) in a number of case series. In this study, we evaluated the efficacy of CAP in the treatment of multiple AKs and assessed morphological changes induced on the skin field of cancerization both clinically and by high-frequency ultrasound (HFUS).MethodsPatients with multiple grade I–II AKs of the scalp and/or face who were resistant or intolerant to conventional field-directed treatments were enrolled. CAP treatments were performed using a microwave-driven argon plasma jet. At baseline and 3 months after the last CAP session, performance indexes were determined using three-dimensional digital pictures and HFUS investigations were performed on a representative Olsen grade II AK and a small spot of clinically unaffected skin within the test area. ResultsTwelve patients were enrolled in the study. All clinical variables showed a statistically significant reduction after CAP. HFUS evaluation revealed that the total, epidermal and dermal thicknesses of the target AKs had not changed with treatment. CAP therapy significantly increased dermal density in both the target AK and the surrounding photodamaged skin and signficantly decreased the thickness of the subepidermal low-echogenic band in the perilesional skin, which is an ultrasound sign of photodamage. ConclusionsCold atmospheric plasma was found to be an effective treatment for patients with multiple AKs. CAP was not followed by skin atrophy. HFUS examiniation showed the CAP improved features of chronic photodamage of the dermis of the skin underlying and surrounding the AK spots.
机译：临床上临床上临床上临床上表现出了临床上的案例系列中的活性角化症（AK）。在这项研究中，我们评估了帽子治疗多个AKS治疗的疗效，并评估了临床和高频超声（HFUS）的癌症皮肤领域的形态学变化。具有头皮的多级I-II AKS的方法。方法和/或抗常规场导向治疗的抗性或不耐受的面孔。使用微波驱动的氩等离子体射流进行帽处理。在基线和3个月后最后一席之地会议后，使用三维数码图片确定性能指标，并在代表性的Olsen级AK上进行HFUS调查，并且在测试区域内的临床上不受影响的皮肤的小点。结果患者注册了研究。所有临床变量都显示出帽子后的统计上显着的减少。 HFUS评估显示，目标AK的总，表皮和皮肤厚度没有随治疗而改变。帽疗法在目标AK和周围的光电抗炎皮肤中显着提高了皮肤密度，并在血管皮肤中引起了潜伏药低回声带的厚度，这是光挖掘的超声标志。结论发现大气血浆是对多个AKS患者的有效治疗方法。皮肤萎缩的帽子不是帽子。 HFUS考试表明，帽子的慢性光电模具的缩小功能的皮肤底层和周围的AK斑点。

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