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首页> 外文期刊>Journal of experimental & clinical cancer research : >ROS and TGFβ: from pancreatic tumour growth to metastasis
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ROS and TGFβ: from pancreatic tumour growth to metastasis

机译：ROS和TGFβ：从胰腺肿瘤生长到转移

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Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A similar contrasting role has been uncovered for reactive oxygen species (ROS) in pancreatic tumorigenesis. Down-regulation of ROS favours premalignant tumour development, while increasing ROS level in pancreatic ductal adenocarcinoma (PDAC) enhances metastasis. Given the functional resemblance, we propose that ROS-mediated processes converge with the spatial and temporal activation of TGFβ signalling and thereby differentially impact early tumour growth versus metastatic dissemination. TGFβ signalling and ROS could extensively orchestrate cellular processes and this concerted function can be utilized by cancer cells to facilitate their malignancy. In this article, we revisit the interplay of canonical and non-canonical TGFβ signalling with ROS throughout pancreatic tumorigenesis and metastasis. We also discuss recent insight that helps to understand their conflicting effects on different stages of tumour development. These considerations open new strategies in cancer therapeutics.
机译：转化生长因子β（TGFβ）信号通路在癌症形成早期抗瘤函数与促进癌症转移的促阶段的促致瘤效应之间的抗致瘤功能。在胰腺肿瘤内酯中的活性氧物质（ROS）被发现类似的对比作用。 ROS的下调良好的肿瘤发育，同时增加胰腺导管腺癌（PDAC）中的ROS水平增强转移。鉴于功能相似，我们提出了ROS介导的过程随着TGFβ信号传导的空间和时间激活而聚集，从而差异地影响早期肿瘤生长与转移性展开。 TGFβ信令和ROS可以广泛地协调细胞过程，并且可以通过癌细胞利用这种齐心协力以促进恶性肿瘤。在本文中，我们重新审视整个胰腺肿瘤发生和转移的ros的典型和非规范TGFβ信号传导的相互作用。我们还讨论了最近的洞察力，有助于了解他们对肿瘤发展不同阶段的矛盾影响。这些考虑因素开辟了癌症治疗剂的新策略。

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