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首页> 外文期刊>Journal of experimental & clinical cancer research : >Noncoding RNAs regulate alternative splicing in Cancer
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Noncoding RNAs regulate alternative splicing in Cancer

机译：noncoding rnas调节癌症中的替代剪接

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AS (alternative splicing) is a fundamental process by which a gene can generate multiple distinct mRNA transcripts to increase protein diversity. Defects in AS influence the occurrence and development of many diseases, including cancers, and are frequently found to participate in various aspects of cancer biology, such as promoting invasion, metastasis, apoptosis resistance and drug resistance. NcRNAs (noncoding RNAs) are an abundant class of RNAs that do not encode proteins. NcRNAs include miRNAs (microRNAs), lncRNAs (long noncoding RNAs), circRNAs (circular RNAs) and snRNAs (small nuclear RNAs) and have been proven to act as regulatory molecules that mediate cancer processes through AS. NcRNAs can directly or indirectly influence a plethora of molecular targets to regulate cis-acting elements, trans-acting factors, or pre-mRNA transcription at multiple levels, affecting the AS process and generating alternatively spliced isoforms. Consequently, ncRNA-mediated AS outcomes affect multiple cellular signaling pathways that promote or suppress cancer progression. In this review, we summarize the current mechanisms by which ncRNAs regulate AS in cancers and discuss their potential clinical applications as biomarkers and therapeutic targets.
机译：AS（替代剪接）是基因可以产生多种不同的mRNA转录物以增加蛋白质多样性的基本过程。影响许多疾病的发生和发展，包括癌症的发生和发展，并且经常被发现参与癌症生物学的各个方面，例如促进侵袭，转移，凋亡抗性和耐药性。 NCRNA（NONCODING RNA）是不编码蛋白质的丰富的RNA类。 NCRNA包括miRNA（microRNA），LNCRNA（长非编码RNA），CircrNA（圆形RNA）和SNRNA（小核RNA），并且已被证明是作为调节癌症过程的调节分子通过。 NCRNA可以直接或间接地影响多种分子靶标以在多个水平下调节顺式作用元件，转发因子或前mRNA转录，影响作为过程并产生可变的剪接同种型。因此，NCRNA介导的结果影响多种细胞信号传导途径，促进或抑制癌症进展。在本综述中，我们总结了NCRNAS调节的目前机制，并将其潜在的临床应用作为生物标志物和治疗靶标。

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