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首页> 外文期刊>Journal of Thoracic Disease >Efficacy of a novel chest tube system in a swine model of hemothorax
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Efficacy of a novel chest tube system in a swine model of hemothorax

机译：新型胸管系统在血小新区猪型模型中的疗效

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Background: Tube thoracostomy is the definitive treatment for most significant chest trauma, including injuries resulting in pneumothorax, hemothorax, and hemopneumothorax. However, traditional chest tubes fail to sufficiently remove blood up to 20% of the time (i.e., retained hemothorax), which can lead to empyema and fibrothorax, as well as significant morbidity and mortality. Here we describe the use of a novel chest tube system in a swine model of hemothorax. Methods: This was an intra-animal-paired, randomized-controlled study of hemothorax evacuation using the PleuraPath? Thoracostomy System (PPTS) compared to a traditional chest tube in large Yorkshire-Landrace swine (75–85 kg). One liter of autologous whole blood was infused into each pleural cavity simultaneously with subsequent drainage from each device individually monitored for a total of 120 minutes, before the end of the experiment and necroscopy. Results: Six animals completed the full protocol. On average, the PPTS removed 17% more blood (P=0.049) and left 19.1% less residual hemothorax (P=0.023) as compared to the standard of care during the first two hours of use. No complications or iatrogenic injury were identified in any animal for either device. Conclusions: The novel PPTS device was superior to the traditional chest tube drainage system in this acute, large-animal model of retained hemothorax. While this study supports clinical translation, further research will be required to assess efficacy and optimize device use in humans.
机译：背景：管胸形术是最明显的胸部创伤的定义治疗，包括伤害肺炎，血管和血红蛋白。然而，传统的胸管不能充分地去除血液，高达20％的时间（即保留的血小影），这可以导致脓胸和纤维嗜胞外，以及显着的发病率和死亡率。在这里，我们描述了新型胸管系统在Hemothorax的猪模型中的使用。方法：这是使用Pleurapath的动物内部对血管疏散的血液疏散性研究吗？ Thoracostomy系统（PPTS）与大型约克郡 - Landrace Swine（75-85千克）的传统胸管相比。一升的自体全血对每个胸腔的整个胸腔同时注入每个胸腔腔中，随后的每种器件的排气分别监测总共120分钟，在实验结束之前和核心检查之前。结果：六只动物完成了完整的协议。平均而言，与前两小时的护理标准相比，PPT将移除17％（P = 0.049），并留下19.1％较少的残留血管（P = 0.023）。在任何一种装置中没有在任何动物中鉴定任何并发症或对生殖损伤。结论：该新型​​PPTS装置优于该急性胸管排水系统，急性胸管排水系统保留的血管库。虽然本研究支持临床翻译，但需要进一步研究来评估人类的疗效和优化装置。

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