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首页> 外文期刊>Journal of Thoracic Disease >Respiratory health effects of residential individual and cumulative risk factors in children living in two cities of the Pearl River Delta Region, China
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Respiratory health effects of residential individual and cumulative risk factors in children living in two cities of the Pearl River Delta Region, China

机译：中国珠江三角洲地区两个城市儿童住宅个体和累积危险因素的呼吸系卫效应

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Background: Indoor environment is complex, with many factors potentially interacting with each other to affect health. However, previous studies have usually focused on effect of a single factor. Assessment of the combined effects of multiple factors can help with understanding the overall health risk. Methods: A cross-sectional study was conducted among 2,306 school children in Guangzhou and Shenzhen. Questionnaire data on respiratory symptoms and diseases were collected along with sociodemographic and residential environmental information. A subset of children (N=987) were measured for their lung function. A random forest algorithm was applied to screen the top-ranked indoor environmental exposure variables and to form a composite index for cumulative risk of indoor pollution (CRIP). Logistic regressions were conducted to analyze the independent effect of single indoor environmental risk factors and the combined effect of CRIP on children’s respiratory health. Multiple linear regressions were used to examine the independent and combined effects of indoor environmental exposure on lung function. Results: We found that home dampness and molds as well as environmental tobacco smoke (ETS) were significantly and independently associated with increased prevalence of children’s respiratory symptoms and diseases and with reduced lung function. A higher CRIP level was significantly associated with increased risk of cough with cold (OR =1.37, 95% CI: 1.05–1.79) and wheeze (OR =2.71, 95% CI: 1.16–6.34). A higher CRIP level was also associated with reduced lung function measured as FVC, FEV 1 , PEF, FEF 25% , FEF 25–75% and VC. Conclusions: In children living in the subtropical region of the Pearl River Delta, home dampness and the presence of mold as well as ETS were individual risk factors for children’s respiratory health. The composite CRIP index was associated with respiratory symptoms and lung function, suggesting the utility of this index for predicting the combined effects of multiple risk factors.
机译：背景：室内环境是复杂的，许多因素可能互相互动以影响健康。然而，之前的研究通常集中于单一因素的影响。评估多种因素的综合影响可以有助于了解整体健康风险。方法：广州和深圳的2,306名儿童横断面研究进行了横断面研究。收集了关于呼吸系统症状和疾病的问卷数据以及社会渗透和住宅环境信息。测量其肺功能的儿童（n = 987）的子集。应用随机森林算法以筛选排级室内环境暴露变量，并形成用于室内污染（CRIP）的累积风险的复合指标。进行了物流回归，以分析单一室内环境风险因素的独立效应以及削减对儿童呼吸系统健康的综合影响。多元线性回归用于检查室内环境暴露对肺功能的独立和组合效果。结果：我们发现家用湿度和模具以及环境烟草烟雾（ETS）显着且与儿童呼吸道症状和疾病的流行增加和肺功能降低。较高的削减水平与咳嗽咳嗽的风险增加显着相关（或= 1.37,95％CI：1.05-1.79）和喘息（或= 2.71,95％CI：1.16-6.34）。较高的削减水平也与测量为FVC，FEV 1，PEF，FEF 25％，FEF 25-75％和VC测量的降低肺功能相关。结论：在珠江三角洲亚热带地区的儿童，家庭湿度和模具的存在以及ETS是儿童呼吸健康的个体危险因素。复合削减指数与呼吸系统症状和肺功能有关，这表明该指标预测多种风险因素的综合影响的效用。

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