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首页> 外文期刊>BMC Cancer >Characteristics of interval gastric neoplasms detected within two years after negative screening endoscopy among Koreans
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Characteristics of interval gastric neoplasms detected within two years after negative screening endoscopy among Koreans

机译：在韩国负筛查内窥镜检查后两年内检测到间隔胃肿瘤的特征

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BACKGROUND:In Korea, where gastric cancer is highly prevalent, biennial endoscopy is recommended among individuals over 40. Even under regular screening, some are still diagnosed at advanced stages. We aimed to identify characteristics of interval gastric neoplasms (IGNs) with rapid progression.RESULTS:Newly-diagnosed gastric neoplasms detected in screening endoscopy between January 2004 and May 2016 were reviewed. Among them, those who had previous endoscopy within 2 years were enrolled. Endoscopic findings, family history of gastric cancer, smoking, and H. pylori status were analysed. Totally, 297 IGN cases were enrolled. Among them, 246 were endoscopically treatable IGN (ET-IGN) and 51 were endoscopically untreatable IGNs (EUT-IGN) by the expanded criteria for endoscopic submucosal dissection. Among EUT-IGNs, 78% were undifferentiated cancers (40/51) and 33% showed submucosal invasion (13/40). They were median 2.0?cm in size and more commonly located in the proximal stomach than ET-IGNs (70.6% vs. 41.9%, p??0.001). EUT-IGN was independently related with age??60 (OR, 2.09; 95%CI, 1.03-4.26, p?=?0.042), H. pylori (OR, 2.81; 95%CI, 1.20-6.63, p?=?0.018), and absent/mild gastric atrophy (OR, 2.67; 95%CI, 1.25-5.72, p?=?0.011). Overall and disease-specific survival were not significantly different between the two groups, however EUT-IGN tended to have short disease-specific survival (overall survival, p?=?0.143; disease-specific survival, p?=?0.083).CONCLUSIONS:Uniform screening endoscopy with two-year interval seems not enough for rapid-growing gastric neoplasms, such as undifferentiated cancers. They tended to develop in adults younger than 60 with H. pylori infection without severe gastric atrophy. More meticulous screening, especially for proximal lesions is warranted for adults younger than 60 with H. pylori infection before development of gastric atrophy.
机译：背景：在韩国，其中胃癌高度普遍，在40岁以上的个体中建议双年内窥镜检查。即使在常规筛查下，一些仍然仍在诊断为先进阶段。我们旨在鉴定快速进展的间隔胃肿瘤（IGNS）的特征。结果：综述了在2004年1月至2016年1月期间检测到筛查内窥镜检查中的新诊断胃肿瘤。其中，在2年内患有先前内窥镜检查的人入学。分析了内窥镜调查结果，分析了胃癌的家族史，吸烟和H.幽门螺杆菌状况。完全，注册了297个IGN病例。其中，246是内镜上可治疗的IGN（ET-IGN），通过扩大的内窥镜粘膜释放的标准进行内窥镜上未经治疗的IMG（EUT-IGN）。在Eut-Ign中，78％是未分化的癌症（40/51）和33％显示粘膜侵袭（13/40）。它们的中位数2.0？厘米的大小，更常见于近端胃，而不是Et-Igns（70.6％vs.41.9％，p≤≤0.001）。 Eut-Ign与年龄无关？<60（或2.09; 95％CI，1.03-4.26，p？= 0.042），H.Pylori（或2.81; 95％CI，1.20-6.63，P. ？=？0.018），缺乏/轻度胃萎缩（或2.67; 95％CI，1.25-5.72，P？= 0.011）。两组之间总体和疾病特异性的存活率没有显着差异，然而EUT-IGN往往具有短暂的疾病特异性存活（总体存活，P？= 0.143;疾病特异性存活，P？= 0.083）。CONCLUSIONS ：均匀的筛选内窥镜检查具有两年间隔的内窥镜似乎不足以用于快速生长的胃肿瘤，例如未分化的癌症。他们倾向于在没有严重胃萎缩的H.幽门螺杆菌的成年人中发展成年人。更细致的筛查，特别是对于在胃萎缩之前，在60瓣幽门螺杆菌感染的成年人需要对近端病变进行保证。

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