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首页> 外文期刊>Cureus. >Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery
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Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery

机译：伽马刀放射外科术后前庭施瓦科瘤患者的听觉抗度显像特征

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Objective In this study, we aimed to investigate whether there is any change in diffusion tensor imaging (DTI) parameters in ipsilateral and contralateral auditory pathways after Gamma Knife radiosurgery (GKR) in patients with vestibular schwannoma (VS) and the relationship between radiosurgery variables. Methods Sixty-six patients were evaluated with MRI and DTI before and after GKR. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA)?were measured from the bilateral lateral lemniscus (LL), inferior colliculus (IC), medial geniculate body (MGB), and Heschl's gyrus (HG). Results There was no significant difference in ADC and FA values obtained from bilateral LL, IC, and MGB before and after radiosurgery. However, there was a significant difference between pretreatment and post-radiosurgery contralateral HG ADC values. The ADC values obtained from the contralateral HG and IC positively correlated with the duration after radiosurgery. As the duration after radiosurgery increases, the difference between the ADC values obtained from ipsilateral and contralateral HG also increases. Conclusion The high ADC values in the contralateral HG after radiosurgery may indicate microstructural alterations such as demyelination and axonal loss. Radiation exposure doses to the brainstem and cochlea are the most important factors that can cause microstructural damage to the auditory pathways. When planning radiosurgery, extreme care should be taken to prevent the harmful effects of radiation on the auditory pathways.
机译：目的在这项研究中，我们旨在调查前庭施瓦新瘤（VS）患者γ刀放射前肠杆菌（GKR）和放射外科变量之间的关系的伽马刀放射牢房（GKR）后的扩散张量成像（DTI）参数的发生变化。方法在GKR之前和之后用MRI和DTI评估六十六名患者。表观扩散系数（ADC）和分数各向异性（FA）是由双侧横向Lemniscus（LL），劣质小学（IC），内侧遗传体（MGB）和Heschl的转象（Hg）测量的。结果从双侧LL，IC和放射前后的双侧LL，IC和MGB获得的ADC和FA值没有显着差异。然而，预处理和放射后外科腹侧HG ADC值之间存在显着差异。从对侧HG和IC获得的ADC值与放射外科术后持续时间呈正相关。随着放射外科的持续时间增加，从同侧和对侧Hg获得的ADC值之间的差异也增加。结论放射外科术后对侧HG中的高ADC值可能表示微观结构改变，例如脱髓鞘和轴突损失。辐射曝光剂量为脑干和耳蜗是最重要的因素，可能导致听觉途径的微观结构损伤。在规划放射外科手术时，应采取极端护理以防止辐射对听觉途径的有害影响。

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