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首页> 外文期刊>International journal of infectious diseases : >Splenic volume on computed tomography scans is associated with mortality in patients with sepsis
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Splenic volume on computed tomography scans is associated with mortality in patients with sepsis

机译：计算断层扫描扫描上的脾体积与败血症患者的死亡率有关

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Objectives The spleen is a key organ of the immune system. Asplenia has been reported to increase the risk of sepsis from overwhelming post-splenectomy infection. However, there are few reports on the association between splenic volume and mortality in patients with no history of splenectomy. This study focused on splenic volume of patients with sepsis and evaluated the association between splenic volume and mortality. Methods We retrospectively investigated 232 patients with sepsis. The splenic volume was calculated by using computed tomography scans obtained on admission. The patients were categorized into tertiles based on their splenic volume, and the relationship between splenic volume and mortality was evaluated. Odds ratio curves based on splenic volume were created to assess the continuous associations between splenic volume and outcome with a logistic regression model. Results The patients with sepsis were divided into three groups according to the first (73.6 cm 3 ) and second (128.7 cm 3 ) tertile values of splenic volume. Kaplan–Meier estimation of the probability of the patients’ survival followed up to 28 days showed significant differences between the groups ( p = 0.03). The hazard ratio for 28-day mortality in the first tertile group was 3.46 (95% CI 1.3–10.2; p = 0.01) as compared with patients in the third tertile group. Patients with smaller spleens had increased odds ratios for mortality in the logistic regression model. Conclusions Splenic volume appeared to be an independent predictor of poor prognosis.
机译：目标脾脏是免疫系统的关键器官。据报道，缺乏症是从压倒性后切除术治疗中增加败血症的风险。然而，没有关于脾切除术病史的患者脾剧性和死亡率之间的报道。本研究重点关注败血症患者的脾体积，并评估了脾体积和死亡率之间的关联。方法回顾性研究232例败血症患者。通过使用在入院时获得的计算机断层扫描扫描来计算脾体积。根据其脾剧，患者被分类为泰姬，评价脾体积与死亡率之间的关系。产生基于脾脏体积的差异曲线，以评估脾剧性与逻辑回归模型之间的连续关联。结果败血症患者分为三组，根据第一（73.6cm 3）和第二次（128.7cm 3）的脾体积的三组（128.7cm 3）。 Kaplan-Meier估算患者存活率的概率随访28天显示群体之间的显着差异（P = 0.03）。与第三张力集团中的患者相比，第一个TERTILE组28天死亡率的危险比为3.46（95％CI 1.3-10.2; p = 0.01）。脾脏患者在后勤回归模型中具有增加的死亡率。结论脾脏体积似乎是预后不良的独立预测因子。

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