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首页> 外文期刊>International journal of infectious diseases : >Comparison of Roche and Lumipulse quantitative SARS-CoV-2 antigen test performance using automated systems for the diagnosis of COVID-19
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Comparison of Roche and Lumipulse quantitative SARS-CoV-2 antigen test performance using automated systems for the diagnosis of COVID-19

机译：利用自动化系统对Covid-19诊断的自动化系统比较罗氏和清醒定量SARS-COV-2抗原试验性能的抗原试验性能

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide. Here, we evaluated the performance of two quantitative antigen (Ag) tests, the Roche and Lumipulse Ag tests, using automated platforms. Methods We collected 637 nasopharyngeal swab samples from 274 individuals. Samples were subjected to quantitative reverse transcription PCR (RT-qPCR), the Roche Ag test and Lumipulse Ag test. Results When RT-qPCR was used as a reference, the overall concordance rate of the Roche Ag test was 77.1% (491/637) with 70.0% (341/487) sensitivity and 100% specificity (150/150). When inconclusive results of the Lumipulse Ag test were excluded, the overall concordance rate of the Lumipulse Ag test was 88.3% (467/529) with 84.8% (330/389) sensitivity and 97.9% (137/140) specificity. The overall concordance rate between the Roche and Lumipulse Ag tests was 97.9% (518/529) with 96.7% (322/333) sensitivity and 100% (196/196) specificity. Quantitative Ag levels determined using the Roche and Lumipulse Ag tests were highly correlated (R 2 = 0.922). The Roche and Lumipulse Ag tests showed high concordance up to nine days after symptom onset, with progressively lower concordance after that. Conclusions The Roche and Lumipulse Ag tests showed equivalent assay performance and represent promising approaches for diagnosing coronavirus disease 2019.
机译：背景，严重急性呼吸综合征冠状病毒2（SARS-COV-2）继续在全球范围内传播。在这里，我们评估了使用自动平台的两种定量抗原（AG）测试，Roche和Lumulse AG测试的性能。方法从274个个体收集637个鼻咽拭子样本。对样品进行定量逆转录PCR（RT-QPCR），Roche Ag试验和液化Ag试验。结果RT-QPCR作为参考，罗氏AG试验的整体一致性率为77.1％（491/637），70.0％（341/487）敏感性和100％特异性（150/150）。当少脉冲AG试验的不确定结果被排除在外时，Lumpulse AG试验的总条率为88.3％（467/529），84.8％（330/389）敏感性，97.9％（137/140）特异性。 Roche和Lumipulse AG测试之间的总体一致性率为97.9％（518/529），96.7％（322/333）敏感性和100％（196/196）特异性。使用Roche和Lumipulse Ag测试测定的定量Ag水平高度相关（R 2 = 0.922）。罗氏和少脉冲AG测试显示症状发作后九天高达9天，在此之后逐步降低。结论罗氏和液化术效应表现出等效的测定性能，并表示2019年冠状病毒疾病的有前途的方法。

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