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首页> 外文期刊>BMC Infectious Diseases >REDuction of Antibiotic RESistance (REDARES) in urinary tract infections using treatments according to national clinical guidelines: study protocol for a pragmatic randomized controlled trial with a multimodal intervention in primary care
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REDuction of Antibiotic RESistance (REDARES) in urinary tract infections using treatments according to national clinical guidelines: study protocol for a pragmatic randomized controlled trial with a multimodal intervention in primary care

机译：根据国家临床指南，使用治疗方法减少尿路感染的尿路感染：用于务实介入的务实干预的务实随机对照试验的研究方案

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Urinary tract infections (UTIs) are a common cause of prescribing antibiotics in family medicine. In Germany, about 40% of UTI-related prescriptions are second-line antibiotics, which contributes to emerging resistance rates. To achieve a change in the prescribing behaviour among family physicians (FPs), this trial aims to implement the guideline recommendations in German family medicine. In a randomized controlled trial, a multimodal intervention will be developed and tested in family practices in four regions across Germany. The intervention will consist of three elements: information on guideline recommendations, information on regional resistance and feedback of prescribing behaviour for FPs on a quarterly basis. The effect of the intervention will be compared to usual practice. The primary endpoint is the absolute difference in the mean of prescribing rates of second-line antibiotics among the intervention and the control group after 12?months. To detect a 10% absolute difference in the prescribing rate after one year, with a significance level of 5% and a power of 86%, a sample size of 57 practices per group will be needed. Assuming a dropout rate of 10%, an overall number of 128 practices will be required. The accompanying process evaluation will provide information on feasibility and acceptance of the intervention. If proven effective and feasible, the components of the intervention can improve adherence to antibiotic prescribing guidelines and contribute to antimicrobial stewardship in ambulatory care. Trial registration?DRKS, DRKS00020389, Registered 30 January 2020, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00020389 .
机译：尿路感染（UTI）是在家庭医学中规定抗生素的常见原因。在德国，约有40％的UTI相关的处方是二线抗生素，这有助于出现抗性率。为了实现家庭医生（FPS）中规定行为的变化，本试验旨在实施德国家族医学的指导建议。在随机对照试验中，将在德国四个地区的家庭实践中开发和测试多式化干预。干预将由三个要素组成：有关指南建议的信息，有关区域抵抗的信息以及季度FPS对FPS的规定行为的反馈。干预的效果将与通常的做法进行比较。主要终点是在12月期间干预和对照组的第二线抗生素规定率的平均值的绝对差异。为了在一年后检测处方率的10％差异，显着性水平为5％，功率为86％，需要每组57个实践的样本量。假设辍学率为10％，将需要总数为128种实践。随附的过程评估将提供有关可行性和接受干预的信息。如果证明有效和可行，干预的组成部分可以改善抗生素的处方指南的依从性，并有助于在动态护理中的抗微生物管制。试用注册？DRKS，DRKS00020389，注册202020年1月30日，https://www.drks.de/drks_web/navigate.do?wavigationId=trial.html&trial_id=drks00020389。

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