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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes
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Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes

机译：纤维增生性疾病和糖尿病：了解PEYRONIE疾病，Dupuytren病和糖尿病之间的病理生理关系

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Introduction Fibrosis is characterized by dysregulation and accumulation of extracellular matrix. Peyronie's disease and Dupuytren disease are fibroproliferative disorders of the tunica albuginea of the penis and fascia of the hand, respectively. Chronic hyperglycaemia due to diabetes mellitus can also lead to tissue injury and fibrosis. A meta‐analysis has shown a relationship between Dupuytren disease and diabetes (overall odds ratio, 3.1; 95% confidence interval, 2.7‐3.5). This review explores commonalities in the pathogenesis of Peyronie's disease, Dupuytren disease and diabetes. Methods A search of the PubMed database was conducted using the search terms “diabetes” AND “Peyronie's disease”; and “diabetes” AND “Dupuytren.” Results Genome‐wide association and gene expression studies conducted with tissue from people with Peyronie's disease or Dupuytren disease identified signalling pathways associated with wingless‐type mammary‐tumour virus integration site signalling, extracellular matrix modulation and inflammation. Biochemical studies confirmed the importance of these pathways in the pathogenesis of fibrosis with Peyronie's disease and Dupuytren disease. Dysregulation of matrix metalloproteinase activity associated with extracellular matrix breakdown was implicated in fibroproliferative complications of diabetes and in the aetiology of Peyronie's disease and Dupuytren disease. A notable percentage of people with diabetes have comorbid Peyronie's disease and/or Dupuytren disease. Conclusions Studies have not been performed to identify fibroproliferative pathways that all 3 conditions might have in common, but data suggest that common pathways are involved in the fibroproliferative processes of Peyronie's disease, Dupuytren disease, and diabetes.
机译：引入纤维化的特征在于细胞外基质的失调和积累。 Peyronie的疾病和Dupuytren疾病分别是阴茎和手柄筋膜的纤维增生性疾病。由于糖尿病患者的慢性高血糖也可以导致组织损伤和纤维化。 Meta分析显示了Dupuytren病和糖尿病之间的关系（总数比，3.1; 95％置信区间，2.7-3.5）。本综述探讨了Peyronie疾病，Dupuytren病和糖尿病发病机制的常见。方法使用搜索项“糖尿病”和“Peyronie氏病”进行PubMed数据库的搜索;和“糖尿病”和“dupuytren”。结果基因组 - 宽协会和基因表达研究与PEYRONIE疾病或Dupuytren病的组织进行了与无翼式乳腺肿瘤病毒整合现场信号传导相关的信号通路，细胞外基质调制和炎症。生物化学研究证实了这些途径在纤维化和佩拜病病和Dupuytren病的发病机制中的重要性。与细胞外基质崩解相关的基质金属蛋白酶活性的失调涉及糖尿病的纤维增生并发症，并在佩雷诺伊病和Dupuytren病的疾病中。糖尿病患者的显着百分比具有共道的PEYRONIE的疾病和/或杜普霉菌病。结论尚未进行研究以鉴定纤维增生途径，即所有3条件可能具有共同的群体，但数据表明常见的途径涉及PEYRONIE疾病，Dupuytren病和糖尿病的纤维增生过程。

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