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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Effect of 12‐week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial
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Effect of 12‐week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial

机译：12周连续阳性气道压力治疗对2型糖尿病和阻塞性睡眠呼吸暂停的连续葡萄糖监测评估葡萄糖水平的影响; 随机对照试验

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Aim Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes (T2D). The aim was to investigate the effect of a 12‐week treatment with continuous positive airway pressure (CPAP) on glycaemic control assessed by continuous glucose monitoring (CGM), HbA1c and fasting blood glucose in patients with T2D and newly detected OSA. Methods In a randomized controlled multicentre study, 72 participants with T2D and moderate to severe OSA (78% male, age 62?±?7, AHI 35?±?15) were recruited from outpatient clinics in three Danish hospitals and were randomized to CPAP intervention or control. The main outcome was glycaemic control assessed by 6?days CGM at baseline and after 12‐week therapy, as well as by HbA1c and fasting blood glucose. Results No significant changes were found in average glucose levels, time in glucose range, time with hypoglycaemia, time with hyperglycaemia or coefficient of variability. HbA1c decreased 0.7?mmol/mol (0.07%; P =?.8) in the CPAP group and increased 0.8?mmol/mol (0.08%; P =?.6) in the control group (intergroup difference, P =?.6). Fasting blood glucose increased by 0.2?mmol/L ( P =?.02) in the CPAP group and by 0.4?mmol/L ( P =?.01) in the control group (intergroup difference, P =?.7). In a prespecified subgroup analysis comparing participants with high adherence (minimum usage of four hours/night for 70% of all nights) to CPAP to the control group, no significant changes were observed either, although these participants had a tendency towards better glycaemic indices. Conclusions CPAP treatment for 12?weeks does not significantly change glycaemic control in patients with type 2 diabetes and OSA.
机译：AIM阻塞性睡眠呼吸暂停（OSA）在2型糖尿病（T2D）中经常出现。目的是探讨通过连续葡萄糖监测（CGM），HBA1c和T2D患者的连续葡萄糖监测（CGM），HBA1c和空腹血糖评估的血糖对照对血糖对照治疗的效果。在随机对照的多期面研究中，72名与T2D和中度至严重OSA的参与者（78％男性，62岁，62岁？±7，AHI 35？±15）是从三个丹麦医院的门诊诊所招募，并随机到CPAP干预或控制。主要结果是在基线和12周治疗后的6？天CGM和HBA1C和空腹血糖后评估的血糖控制。结果在平均血糖水平，葡萄糖范围内的时间没有显着变化，低血糖血症的时间，具有高血糖或可变性系数的时间。在CPAP组中，HBA1C降低0.7mmol / mol（0.07％; p = 3），在对照组中增加0.8毫升/ mol（0.08％; p = 3）（互殖差异，p =？ 6）。在CPAP组中，空腹血糖增加0.2？mmol / L（p =β.02），并在对照组中×0.4mmol / l（p =β.01）（互连差异，p = 7）。在预先收入的亚组分析中，将参与者的高粘附性比较（最低使用4小时/夜，每晚70％）到对照组的CPAP，虽然这些参与者对更好的血糖指数倾向于倾向，但也没有观察到重大变化。结论CPAP治疗12〜T周不会显着改变2型糖尿病和OSA患者的血糖控制。

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