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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >A comparison in the ability to detect diabetic retinopathy between fasting plasma glucose and HbA1c levels in a longitudinal study
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A comparison in the ability to detect diabetic retinopathy between fasting plasma glucose and HbA1c levels in a longitudinal study

机译：在纵向研究中检测禁食血浆葡萄糖与HBA1C水平之间的糖尿病视网膜病变的能力的比较

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Aims:The relationship between HbA1c and diabetic retinopathy is expected to differ between different races. In this study, we verified which of HbA1c and fasting plasma glucose (FPG) is more effective for detecting the diabetic retinopathy longitudinally in a Japanese population.Materials and Methods:The study subjects underwent health examinations twice (including eye test and questionnaire of lifestyle and health) in 2008-2009 (baseline) and in 2012-2013 (4-year follow-up). Both non-DM and DM patients at baseline were included as the participants. Of these participants, who had not been diagnosed with retinopathy at the baseline survey (n?=?2427; 2150 men and 277 women) had eye fundus photographs taken four years later (follow-up survey). The odds ratios of incidence of retinopathy according to the eight groups of FPG and HbA1c were estimated using multiple logistic regression analysis adjusted for sex and age. Receiver operator characteristic analysis was used to evaluate each value associated with the presence or absence of retinopathy.Results:The odds ratios (95% confidence intervals) of incidence of retinopathy by HbA1c level categories, in ascending order, were 1.0 (ref.), 5.66 (1.14-28.26), 1.69 (0.24-12.04), 3.03 (0.50-18.28), 1.04 (0.09-11.59), 4.73 (0.78-28.69), 4.12 (0.74-22.85) and 24.47 (5.61-106.75). For both FPG and HbA1c levels, the odds ratio for the development of retinopathy increased linearly with the increases in the levels FPG and HbA1c, and no clear threshold was observed. The AUC values (SE) for FPG and HbA1c were almost the same, at 0.750 (0.046) and 0.732 (0.048).Conclusions:It was clarified that the higher the level of FPG and HbA1c was, the higher the incidence of retinopathy after 4?years was. There was no clear threshold. The detection ability of the incidence of retinopathy was almost the same between FPG and HbA1c, suggesting it is possible to detect the risk of retinopathy by HbA1c only.? 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
机译：目的：HBA1C与糖尿病视网膜病的关系预计不同种族之间的关系。在这项研究中，我们验证了哪种HBA1C和空腹血浆葡萄糖（FPG）更有效地在日本人群中纵向检测糖尿病视网膜病变。材料和方法：研究受试者接受了两次健康检查（包括生活方式的眼睛测试和调查问卷和健康）2008 - 2013年（基线）和2012-2013（4年的随访）。基线的非DM和DM患者作为参与者包括在内。在这些参与者中，在基线调查中未被诊断出患有视网膜病变（N？= 2427; 2150男性和277名女性）在四年后拍摄了眼底照片（后续调查）。使用对性别和年龄的多元逻辑回归分析估计了根据八组FPG和HBA1C的视网膜病变的差距比率。接收器操作员特征分析用于评估与视网膜病变的存在或不存在相关的每种值。结果：HBA1C水平类别按升序的视网膜病变的发生率（95％置信区间）是1.0（参考文献）， 5.66（1.14-28.26），1.69（0.24-12.04），3.03（0.50-18.28），1.04（0.09-11.59），4.73（0.78-28.69），4.12（0.74-22.85）和24.47（5.61-106.75）。对于FPG和HBA1C水平，随着水平的增加和HBA1C的增加，视网膜病变的发展的差距增加，并且没有观察到透明阈值。 FPG和HBA1C的AUC值（SE）几乎相同，0.750（0.046）和0.732（0.048）。结论：澄清了FPG和HBA1C水平越高，4后的视网膜病变率越高？岁月是。没有明确的门槛。术疗法发生率的检测能力在FPG和HBA1C之间几乎相同，表明只能检测HBA1C视网膜病变的风险。？ 2020作者。 John Wiley＆Sons Ltd.出版的内分泌，糖尿病和新陈代谢

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