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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Glycaemic control and outcomes in children with type 2 diabetes diagnosed at or before 10 years of age
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Glycaemic control and outcomes in children with type 2 diabetes diagnosed at or before 10 years of age

机译：在10岁或之前诊断出2型糖尿病儿童的血糖控制和结果

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Background Type 2 diabetes (T2DM) in children is considered rare before puberty. Objective Describe the characteristics and outcomes of children with T2DM diagnosed at or before 10?years of age. Methods Retrospective electronic medical record review of children diagnosed with T2DM at a University Children's Hospital over 12?years was conducted. Patient characteristics at diagnosis, 2‐3‐year follow‐up, and 4‐5‐year follow‐up were analysed as a whole and by age groups, 5‐8 and 9‐10?years. Results There were 42 children?≤?10?years with T2DM (5‐8‐year age group, n?=?8 and 9‐10‐year age group, n?=?34). There were 88.1% African American, 11.9% Caucasian, and 88.1% females. Body mass index (BMI) was ≥95th percentile in 95.2%. Average BMI z score was 2.5?±?0.4 and higher in the 5‐8‐year age group (2.7?±?0.5 vs 2.4?±?0.4, P =?.02). Average haemoglobin A1C at diagnosis was 10.5?±?2.4%, and improvement was seen at 2‐3?years, but subsequent worsening was noted at 4‐5?years in both age groups. At 4‐5?years after diagnosis, 93.9% required insulin for management of their hyperglycaemia, 21.2% had hypertension requiring treatment, 28.6% had low‐density lipoprotein ≥130?mg/dL, and 28.6% had high‐density lipoprotein 40?mg/dL. Conclusions T2DM at or below 10?years of age disproportionately affected females and ethnic minorities and was associated with morbid obesity. The majority of these children did not achieve glycaemic control and required insulin for management of their hyperglycaemia after 4‐5?years, indicating the need for increased awareness of T2DM and intensive treatment in this special group.
机译：在青春期之前，儿童的背景2型糖尿病（T2DM）被认为是罕见的。目的描述在10年龄或之前诊断的T2DM儿童的特征和结果。方法对12多年儿童医院诊断为T2DM诊断为T2DM的儿童的回顾性电子医学记录评论。诊断的患者特征，2-3年随访和4-5年后续随访人数，以5-8和9-10岁为全年和年龄组进行分析。结果有42个孩子？≤？10？几年与T2DM（5-8岁），N？=？8和9-10年龄组，N？=？34）。有88.1％的非洲裔美国人，11.9％的高加索人和88.1％的女性。体重指数（BMI）≥95百分位数为95.2％。平均BMI Z得分为2.5？±0.4°，5-8岁的年龄组（2.7？±0.5 Vs 2.4？±0.4，P = 3.02）。诊断的平均血红蛋白A1C为10.5？±2.4％，并且在2-3岁时看到了改善？年龄，但随后的恶化在4-5年龄在4-5岁之间指出。在4-5岁时诊断后，93.9％所需的胰岛素用于管理其高血糖，21.2％具有需要治疗的高血压，28.6％具有低密度脂蛋白≥130Ω·mg / dl，28.6％具有高密度脂蛋白＆ 40？mg / dl。结论T2DM在10年或低于10岁以下的年龄，不成比例地影响女性和少数群体，与病态肥胖有关。这些儿童的大多数未在4-5岁后达到血糖控制和所需的胰岛素，以便在4-5岁以后对其高血糖血症进行管理，表明需要提高对该特殊群体的T2DM和密集疗法的认识。

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