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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Complete blood counts with red blood cell determinants associate with reduced beta-cell function in seroconverted Swedish TEDDY children
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Complete blood counts with red blood cell determinants associate with reduced beta-cell function in seroconverted Swedish TEDDY children

机译：用红细胞决定簇的完全血液计数与血清型瑞典泰迪儿童的降低的β细胞功能相关联

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Objectives To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8?years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c. Results HbA1c over time increased by the number of autoantibodies ( p ?.001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c ( p ?.001). A reduction in red blood cell (RBC) counts ( p =?.003), haemoglobin ( p =?.002) and haematocrit ( p =?.006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. Conclusions The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity.
机译：目的探讨胰岛胰腺炎患者胰腺炎患者的完全血统（CBC）的变化是否随着时间的推移与口腔葡萄糖耐量试验（OGTT）和HBA1C有关。方法对杨氏型糖尿病风险增加，德国，瑞典和芬兰的糖尿病风险增加，患儿童糖尿病的环境决定簇。在目前的研究中，89名瑞典泰迪儿童（中位数8.8岁）对一个或多个胰岛自身抗体的阳性呈阳性，随访CBC，OGTT和HBA1C最多5岁（中位数2.3）岁。使用统计混合效果模型来研究CBC和OGTT或HBA1C之间的关联。结果HBA1C随着时间的推移增加了自身抗体的数量（P <。001）。平均粒状血红蛋白（MCH）和平均细胞体积（MCV）的降低均与HBA1C的增加（P <。001）。红细胞（RBC）计数（p =α.003），血红蛋白（P =→002）和血细胞比容（p =β.006）水平与增加的空腹葡萄糖有关。增加红细胞，血红蛋白，血细胞比容和MCH，但红细胞分布宽度（RDW）的水平降低均与增加的空腹胰岛素相关。结论随着HBA1C的增加和RBC减少的RBC索引及其与增加血清血糖儿童的葡萄糖的降低可能反映与胰岛β细胞自身免疫相关的葡萄糖代谢的阴险劣化。

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