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首页> 外文期刊>Diabetes >Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
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Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

机译：瑞典TEDDY儿童中1型糖尿病风险增加的与性别，HLA和胰岛自身抗体相关的白细胞，中性粒细胞和红细胞计数减少

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摘要

Islet autoantibodies (lAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several lAs against insulin, GAD65, or IA-2 (n = 72). CBC was analyzed during longitudinal follow-up in 448 Swedish children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A linear mixed-effects model was used to assess potential association between IA and CBC measurements over time. The white blood cell and neutrophil counts were reduced in children with lAs, primarily in boys. In contrast, girls had lower levels of hemoglobin and hematocrit. Positivity for multiple lAs showed the lowest counts in white blood cells and neutrophils in boys and red blood cells, hemoglobin, and hematocrit in girls. These associations were primarily observed in children with the HLA-DR3-DQ2/DR4-DQ8 genotype. We conclude that the reduction in neutrophils and red blood cells in children with multiple lAs and HLA-DR3-DQ2/DR4-DQ8 genotype may signal a sex-dependent islet autoimmunity detected in longitudinal CBCs.
机译：胰岛自身抗体（IA）在1型糖尿病（T1D）临床发作之前；然而，关于前驱症是否会影响4岁至12岁T1D遗传风险增加的儿童的全血细胞计数（CBC）的知识是有限的。这项研究测试了在没有（n = 376）或有一个或几个针对胰岛素，GAD65或IA-2的lA的4至12岁儿童中，CBC是否发生了改变（n = 72）。在对448位瑞典儿童进行糖尿病青年环境因素（TEDDY）研究的纵向随访过程中，对CBC进行了分析。线性混合效应模型用于评估IA和CBC测量之间随时间的潜在关联。患有lA的儿童（主要是男孩）的白细胞和中性粒细胞计数降低。相反，女孩的血红蛋白和血细胞比容较低。多重lA阳性显示男孩中白细胞和嗜中性粒细胞最低，女孩中红细胞，血红蛋白和血细胞比容最低。这些关联主要在具有HLA-DR3-DQ2 / DR4-DQ8基因型的儿童中观察到。我们得出结论，具有多个lA和HLA-DR3-DQ2 / DR4-DQ8基因型的儿童中性粒细胞和红细胞的减少可能表明在纵向CBC中检测到性别依赖性的胰岛自身免疫性。

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  • 来源
    《Diabetes》 |2018年第11期|2329-2336|共8页
  • 作者

    Falastin Salami; Hye-Seung Lee; Eva Freyhult; Helena Elding Larsson; Ake Lernmark; Carina Torn;

  • 作者单位

    Department of Clinical Sciences, Lund University/Clinical Research Centre, Skane University Hospital, Malmd, Sweden;

    Health Informatics Institute, Department of Pediatrics, University of South Florida, Tampa, FL;

    Department of Medical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden;

    Department of Clinical Sciences, Lund University/Clinical Research Centre, Skane University Hospital, Malmd, Sweden;

    Department of Clinical Sciences, Lund University/Clinical Research Centre, Skane University Hospital, Malmd, Sweden;

    Department of Clinical Sciences, Lund University/Clinical Research Centre, Skane University Hospital, Malmd, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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