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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study
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Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study

机译：患有糖尿病足疾病住院的慢性肾病患者的临床结果：全国回顾性研究

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Introduction Diabetic foot ulcerations or infections (DFUs/DFIs) are common complications of patients with diabetes. This study aimed to explore the impact of non-dialysis and dialysis CKD on hospitalized patients with DFUs/DFIs. Methods A retrospective cohort study was conducted using the National Inpatient Sample database for the years 2017 and 2018. Patients hospitalized for DFUs/DFIs were included in the study. The primary outcome was lower limb amputations. The secondary outcomes were inpatient mortality, sepsis, length of stay (LOS), total hospitalization charges (THC) and disposition. Results A total of 121,815 hospitalizations were included (26.1% non-dialysis CKD; 8.4% dialysis CKD). There was no significant difference in amputation rates between those on non-dialysis CKD (adjusted odds ratio [aOR]: 0.96; 95% confidence interval [CI]: 0.87–1.06) and dialysis CKD (aOR: 1.04, [95% CI: 0.91–1.12]) when compared to non-CKD group. Dialysis CKD group had increased odds of undergoing major amputation (aOR: 1.74, [95% CI: 1.32–2.29]), in-hospital mortality (aOR: 3.77 [95% CI: 1.94–7.31]), sepsis (aOR: 1.83 [95% CI: 1.27–2.62]), longer LOS (adjusted mean difference [aMD]: 1.46 [95 CI: 1.12–1.80) and higher THC (adjusted mean difference [aMD]: $20,148 [95% CI: $15,968-$24,327]). Non-dialysis CKD group had increased odds of sepsis (aOR: 1.36 [95% CI: 1.02–1.82]), less likely to be discharged home (aOR: 0.87 [95% CI: 0.80–0.95]), longer LOS (aMD: 0.91 [95% CI 0.69–1.13]) and higher THC (aMD: $20,148 [95% CI: $15,968–$24,327]). Conclusion Patients with CKD on dialysis had higher odds of undergoing major amputation. CKD increased the odds of in-hospital morbidity and resource utilization, with the most significant is for those on dialysis.
机译：介绍糖尿病足溃疡或感染（DFUS / DFIS）是糖尿病患者的常见并发症。本研究旨在探讨非透析和透析CKD对DFUS / DFIS住院患者的影响。方法采用2017年和2018年的国家住院样品数据库进行了回顾性队列研究。研究患者患有DFUS / DFIS的患者。主要结果是较低的肢体截肢。二次结果是住院性死亡率，败血症，逗留时间（LOS），住院总费用（THC）和处置。结果总共包括121,815名住院治疗（26.1％的非透析CKD; 8.4％透析CKD）。非透析CKD的截肢率没有显着差异（调整后的差距[AOR]：0.96; 95％置信区间[CI]：0.87-1.06）和透析CKD（AOR：1.04，[95％CI： 0.91-1.12]）与非CKD组相比。透析CKD组接受着主要截肢的几率增加了（AOR：1.74，[95％CI：1.32-29]），在医院死亡率（AOR：3.77 [95％CI：1.94-7-7.31]），SEPSIS（AOR：1.83 [95％CI：1.27-2.62]），LOS更长（调整平均差异[AMD]：1.46 [95 CI：1.12-1.80）和更高的THC（调整后平均差异[AMD]：$ 20,148 [95％CI：$ 15,968- $ 24,327 ]）。非透析CKD组的败血症（AOR：1.36 [95％CI：1.02-1.82]）增加，不太可能排放家庭（AOR：0.87 [95％CI：0.80-0.95]），更长的LOS（AMD ：0.91 [95％CI 0.69-1.13]）和更高的THC（AMD：$ 20,148 [95％CI：$ 15,968- $ 24,327]）。结论CKD对透析的患者进行了较高的截肢几率。 CKD增加了院内发病率和资源利用的几率，最重要的是透析的人。

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