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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >The association between glycaemic control during hospitalization and risk of adverse events: A retrospective cohort study
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The association between glycaemic control during hospitalization and risk of adverse events: A retrospective cohort study

机译：住院期间血糖控制与不良事件风险之间的关联：回顾性队列研究

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Introduction Hyperglycaemia is common during hospitalization; glycaemic targets in non-critical care settings have not been well studied. We assessed associations between inpatient glycaemic control and adverse events. Methods We conducted a retrospective cohort study on non-critically ill medical patients hospitalized in a tertiary care hospital between 2015 and 2018. Mean glycaemia during the first four days of hospitalization was categorized as 4.0–7.0?mmol/L, 7.1–10.0?mmol/L and 10.0?mmol/L. The primary outcome was a composite of adverse events including mortality, infections, acute kidney injury, thromboembolic and cardiovascular events. The secondary outcome was hypoglycaemia, defined as any glycaemia 10.0?mmol/L (adjusted OR: 0.98, 95% CI: 0.75–1.28) and the occurrence of adverse events, compared to a glycaemia of 7.1–10.0?mmol/L. Glycaemia of 10.0?mmol/L was associated with an increased risk of hypoglycaemia (adjusted hazard ratio [HR]: 1.72, 95% CI: 1.21–2.45). Hypoglycaemia was associated with adverse events (adjusted OR 1.85, 95% CI 1.31–2.60). Conclusions Neither glycaemia of 4.0–7.0?mmol/L nor glycaemia of 10.0mmol/L during non-critical care hospitalization was associated with increased adverse events. Glycaemia of 10.0?mmol/L was associated with increased hypoglycaemia, likely due to aggressive glucose lowering. These findings highlight the need for further studies to discern optimal inpatient glycaemic targets.
机译：引言高血糖在住院期间很常见;非关键护理环境中的血糖目标尚未得到很好的研究。我们评估了住院性血糖控制和不良事件之间的关联。方法对2015年至2018年间高级护理医院住院的非批判性医疗患者进行了回顾性队列研究。入院前四天的平均糖类血症分为4.0-7.0？MMOL / L，7.1-10.0？MMOL / l和＆ 10.0？mmol / l。主要结果是不良事件的复合事件，包括死亡率，感染，急性肾损伤，血栓栓塞和心血管事件。二次结果是低血糖，定义为任何糖尿病10.0？Mmol / L（调节或：0.98,95％CI：0.75-1.28）和不良事件的发生，而与7.1-10.0莫尔/升的血糖血症相比。糖尿病的＆ 10.0？mmol / L与低血糖风险增加有关（调整后危险比[HR]：1.72,95％CI：1.21-2.45）。低血糖与不良事件有关（调节或1.85,95％CI 1.31-2.60）。结论既不是4.0-7.0？mmol / L也不是糖尿病的＆ 10.0mmol / l在非关键护理住院期间与增加的不良事件相关。糖尿病的＆ 10.0？mmol / L与低血糖增加有关，可能是由于侵蚀性葡萄糖降低。这些发现强调了需要进一步研究以辨别最佳的住院性血糖目标。

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