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首页> 外文期刊>JOR spine. >Single level posterolateral lumbar fusion in a New Zealand White rabbit (Oryctolagus cuniculus) model: Surgical anatomy, operative technique, autograft fusion rates, and perioperative care
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Single level posterolateral lumbar fusion in a New Zealand White rabbit (Oryctolagus cuniculus) model: Surgical anatomy, operative technique, autograft fusion rates, and perioperative care

机译：新西兰白兔（Oryctolagus cuniculus）模型中的单级后水分腰椎融合：手术解剖，手术技术，自体移植融合率和围手术期护理

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Introduction The posterolateral lumbar fusion (PLF) New Zealand White (NZW) ( Oryctolagus cuniculus ) rabbit model is a long‐standing surgical technique for the preclinical evaluation of materials for spinal fusion. A detailed understanding of lumbar spine anatomy and perioperative care requirements of rabbits is imperative for correct execution of the model both scientifically and ethically. This study describes the preoperative procedures and surgical techniques used in single level PLF in a NZW rabbit model as it pertains to the animal husbandry, lumbar spine anatomy, anesthesia, surgical approach, and perioperative care of rabbits in a research setting. Materials and Methods We describe the surgical technique and perioperative patient care for single level PLF in a NZW rabbit model. Medical records from a single research facility were retrospectively reviewed for adult NZW rabbits that underwent single level PLF (L4‐L5) between January 2016 and December 2019. The number of lumbar vertebrae per rabbit, fusion rates at 12?weeks using iliac crest autograft and complications are reported. Skeletal maturity was confirmed by preoperative fluoroscopic and radiographic documented closure of hindlimb physes. Results The PLF rabbit surgical model and perioperative patient care is described. PLF was performed in 868 adult female entire NZW rabbits. The majority of rabbits had seven lumbar vertebrae (620/868; 71.4%), followed by six (221/868; 25.5%), and eight (27/868; 3.1%). Fusion rates at 12?weeks for PLF using iliac crest autograft as assessed by manual palpation and radiographic assessment was 76.9% and 70.0%, respectively. Postoperative complications included occasional partial autograft site wound dehiscence due to self‐trauma. Conclusions For PLF rabbit models, a detailed understanding of the surgical technique, rabbit lumbar anatomy including number of lumbar vertebrae, and dietary and husbandry requirements of rabbits, is essential for execution of the model and animal welfare.
机译：引言后脊椎乳液融合（PLF）新西兰白（NZW）（Oryctolagus cuniculus）兔模型是一种用于脊柱融合材料的临床前评价的长期外科技术。对腰椎解剖学和围手术期护理要求的详细了解兔子必须在科学和道德上正确执行模型。本研究描述了在NZW兔模型中单级PLF中使用的术前手术和手术技术，因为它涉及畜牧业，腰椎解剖学，麻醉，手术方法，以及在研究环境中的兔子的围手术期。材料和方法我们描述了NZW兔模型中单层PLF的手术技术和围手术期患者护理。回顾性从一项研究设施的医疗记录对2016年1月至2019年1月至12月之间的单一级别PLF（L4-L5）进行的成人NZW兔子进行了回顾性。每只兔子的腰椎数，融合率在12？周使用Iliac Crest自体移植物报告了并发症。通过术前荧光透视和射线照相证实了Hindlimb物理学的骨骼成熟。结果描述了PLF兔手术模型和围手术期患者护理。 PLF在868名成年女性整个NZW兔中进行。大多数兔子有七只腰椎（620/868; 71.4％），其次是六（221/868; 25.5％），八（27/868; 3.1％）。使用Iniac Crest自体移植的PLF作为手动触诊和射线照相评估评估的融合率分别为76.9％和70.0％。术后并发症包括偶尔由于自创的自体移植部位伤口裂开。结论PLF兔模型，详细了解外科手术技术，兔腰椎解剖学，包括腰椎数，以及兔子的饮食和饲养和饲养要求，对执行模型和动物福利是必不可少的。

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