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First 70 Days Critical Data Trend for COVID-19 in Four Regions of Northern Italy: A Pilot Study

机译:在意大利北部四个地区Covid-19的前70天至关重要的数据趋势:试点研究

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The new coronavirus syndrome (COVID-19) is a multi-organ pathological manifestation that, in severe forms, causes greater damage to the respiratory system, especially in the lung district with severe respiratory failure. In many cases, especially in elderly patients with high comorbidity degree, the disease can have a rapid course with a fatal outcome. Specifically, the data relating to the four Italian regions most affected by the effects of the new coronavirus Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2), namely Lombardia, Veneto, Emilia Romagna and Piemonte, were assessed. In this work, we decided to focus the analysis only on data relating to patients admitted to the intensive care unit and to patients who died in Italy with COVID-19 in the period 24 February–4 May 2020. We used a data set where each point was an expression not of a single day, but of a longer period of time (date-points method). The article clearly identifies the phases in which the epidemic was articulated at national level and in the observed regions. Both the overall national data and the data referring to the most affected regions show an initial exponential mortality trend up to March 21st approximately. From this point the restrictive measures adopted from March 10th shows their effects and the trend first increases only linearly and then finally decreases, also thanks to the implementation of therapeutic strategies aimed at modulating respiratory distress and the clinical condition of thromboembolism, typical of critical patient COVID-19.
机译:新的冠状病毒综合征(Covid-19)是一种多器官病理表现,以严重的形式导致对呼吸系统的更大损害,特别是在肺区,具有严重的呼吸衰竭。在许多情况下,特别是在具有高合色度的老年患者中,疾病可以在致命结果中具有快速的课程。具体而言,评估了与新的冠状病毒严重急性呼吸综合征-coronavirus-2(SARS-COV-2),即Lombardia,veneto,Emilia romagna和Piemonte影响最大的意大利区域受影响最大影响的四种意大利地区。在这项工作中,我们决定仅关注与入院的患者有关的数据,并在意大利与Covid-19在2月24日 - 4月24日在2020年5月24日中致电的患者。我们使用了每个数据集点是不是一天的表达,但更长的时间段(日期点方法)。本文清楚地确定了疫情在国家一级和观察到的地区阐明的阶段。总体国家数据和涉及最多受影响的地区的数据都表明了大约3月21日的初始指数死亡率趋势。从这一点来看,3月10日通过的限制性措施显示了它们的效果,趋势首先增加了线性,然后终于减少了旨在调节呼吸窘迫的治疗策略和血栓栓塞的临床条件,典型的临界患者Covid -19。

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