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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Carvedilol Induced Toxic Epidermal Necrolysis: A Rare Case Report
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Carvedilol Induced Toxic Epidermal Necrolysis: A Rare Case Report

机译：Carvedilol诱导有毒表皮坏死：罕见的病例报告

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Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe, life threatening immunologically mediated, mucocutaneous, Adverse Drug Reactions (ADR) associated with high mortality which requires immediate medical care. Carvedilol is a non selective adrenergic blocker used for the therapy of heart failure with hypertension, and left ventricular dysfunction following Myocardial Infarction (MI) in clinically stable patients. Hereby, authors report of a 69-year-old male with a history of MI and hypertension, who received Carvedilol at a dose of 75 mg daily and four days after the first dose of carvedilol, patient presented with erythematous maculopapular rash on face, trunk and limbs with fever up to 38°C. Skin biopsy from one of the fresh lesions showed apoptotic keratinoctyes, subepidermal cleft and monocytic infiltrate in the dermis and the findings were compatible with the diagnosis of TEN. Early recognition and cessation of the drug is of prime importance along with apt treatment and supportive care.
机译：史蒂文斯 - 约翰逊综合征（SJ）和有毒表皮坏死（十）是严重的，植物威胁免疫介导，霉菌，不良药物反应（ADR），相关的高死亡率，需要立即医疗。 Carvedilol是一种非选择性肾上腺素能阻滞剂，用于治疗心力衰竭，在临床稳定患者心肌梗死（MI）后左心室功能障碍。因此，作者报告了一名69岁男性的MI和高血压历史，他们在每天75毫克的剂量和第一剂卡维地洛的患者中收到Carvedilol，患者在脸上呈现出红斑的marupopular皮疹和发烧的肢体高达38°C。来自一个新鲜病变之一的皮肤活组织检查显示凋亡的keratinyctyes，皮肤病裂缝和真皮中的单核细胞浸润，结果与十个诊断相容。这种药物的早期识别和停止是素质重要性以及APT治疗和支持性的护理。

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