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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Safety and Efficacy of Fixed Drug Combination Tenofovir, Lamivudine and Efavirenz to Prevent Transmission of HI
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Safety and Efficacy of Fixed Drug Combination Tenofovir, Lamivudine and Efavirenz to Prevent Transmission of HI

机译：固定药物组合的安全性和有效性替诺福韦，拉米夫鲁德和efaviraenz预防嗨传播

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Mother-to-child transmission of HIV can occur during pregnancy, labour, or breastfeeding. The first-line regimen for prophylaxis in HIV infected pregnant women is combination of Tenofovir, Lamivudine and Efavirenz (TLE).Aim:To evaluate the safety and efficacy of the TLE regimen in the Prevention of Mother-To-Child Transmission (PMTCT) of HIV.Materials and Methods: The present hospital-based, retrospective cohort study was conducted at ART centre, Prevention of Parent to Child Transmission (PPTCT) centre, and Department of Medicine, SP Medical College, Bikaner from July 2016 to June 2019. HIV positive gravidas, on triple-drug regimen TLE (Tenofovir 300 mg, Lamivudine 300 mg, Efavirenz 600 mg) before conception and, those detected HIV reactive antenatally during study period were included in this study and started on TLE regimen. After delivery, these newborns were given syrup Nevirapine as per the PPTCT guidelines. Infants were tested with Rapid test and PCR for HIV, at six weeks, six months, 12 months, and 18 months of life.Results: Out of 87 pregnant women, enrolled and delivered at the study institute, 85 were live births and two were stillbirths. Out of 85 live-born babies, four have died during infancy and two were lost to follow-up despite repeated counselling. Five babies were referred to nearby Anti-Retroviral Therapy (ART) centers. So, the study followed 74 babies out of which one girl child was found to be positive for HIV-1 at 18 months of age (transmission rate of HIV was 1.35 and efficacy of TLE 98.65%). No major adverse effects of TLE were noted and all women continued TLE.Conclusion: The use of a triple-drug regimen (TLE) declined the risk of transmission of HIV from mother-to-child at negligible level, without drug resistance and with safety and tolerability as compared to single drug.
机译：怀孕，劳动力或母乳喂养期间，艾滋病毒的母亲到儿童传播。艾滋病病毒感染妇女的预防孕妇的一线方案是替诺福韦，拉米法和efaviraz（TLE）的组合HIV.Materials和方法：目前的医院，回顾性队列研究在艺术中心进行，预防父母到儿童传输（PPTCT）中心，以及2016年7月至2019年6月的Bikaner医学院。艾滋病毒在概念之前，在三重药物方案TLE（Tenofovir 300mg，Lamivirz 300mg，Efavirenz 600mg）之前的阳性重生，并且在本研究中纳入研究期间检测到的HIV反应性的那些，并在TLE方案开始。递送后，根据PPTCT指南，将这些新生儿进行糖浆Nevirapine。婴儿用快速试验和艾滋病毒的PCR测试，六周，六个月，12个月和18个月的生命。结果：在87名孕妇中，注册和交付在学习机构，85名是活产，两个人死产。在85名活的婴儿中，四个已经在婴儿期死了，尽管反复咨询，但两个人失去了随访。五名婴儿被提及附近的抗逆转录病毒治疗（艺术）中心。因此，该研究遵循74个婴儿，其中一个女孩被发现在18个月的HIV-1阳性上阳性（艾滋病毒的传播率为1.35，TLE的疗效98.65％）。没有注意到TLE的主要不良反应，所有女性持续TLE.CONCLUSEUSION：使用三重药物方案（TLE）的使用拒绝在少量抗耐药性和安全性处于忽略的水平母婴传播艾滋病毒的风险与单一药物相比的耐受性。

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