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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Urinary Kidney Injury Molecule-1 as an Early Detection Biomarker for Diagnosis of Acute Kidney Injury in Patients of Snake Bite
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Urinary Kidney Injury Molecule-1 as an Early Detection Biomarker for Diagnosis of Acute Kidney Injury in Patients of Snake Bite

机译：尿肾损伤分子-1作为早期检测生物标志物，用于诊断蛇咬患者急性肾损伤的生物标志物

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Acute Kidney Injury (AKI) refers to a sudden impairment of kidney function that results in the retention of nitrogenous waste products. Acute tubular necrosis involves localised necrosis of epithelial lining in renal tubules. A soluble form of human Kidney Injury Molecule-1 (KIM-1) is a type1 membrane-spanning protein which lends epithelial cells the capacity to perceive and phagocytose dead cells in post ischemic kidney.Aim: To estimate urinary KIM-1 level in patients with snake bite as a potential biomarker for early detection for AKI.Materials and Methods: This was an analytical case-control study, which was conducted on 100 patients admitted for snake bite at Thanjavur Medical College and hospital, Thanjavur, Tamil Nadu, India, from January 2014 to August 2014. Patients without AKI were regarded as controls and those who developed AKI were considered as cases. Blood and urine samples were collected and analysed for urinary KIM-1 by Enzyme-Linked Immune Sorbent Assay (ELISA), method, serum creatinine (by kinetic JAFFE’S method) and serum urea (by Urease- glutamate dehydrogenase method). Student’s t-test was used and p-value<0.05 was regarded significant. Pearson’s correlation coefficient was used to assess correlation between measured parameters.Results: Among 100 patients 44 were diagnosed as patients having AKI and 56 of them did not develop AKI. No significant difference was found in urinary KIM-1 values between age group of <40 years and age group ≥40 years in cases (p-value=0.39) and in controls (p-value=0.65). A significant elevation of urinary KIM-1 was seen among cases of snake bite who developed AKI. Urinary KIM-1 levels were found to significantly rise within 24 hours of admission (p-value<0.001), whereas, serum creatinine and urea values were not increased until the day 3 of nephrotoxic trauma. The urine KIM-1 and serum creatinine on day 1 had negligible correlation (r-value=0.093, p-value=0.54) and urine KIM-1 and urea on day 1 had low positive correlation (r-value=0.380, p-value=0.011). With progressive damage to the kidneys, a positive correlation was found between urine KIM-1 and serum urea (r-value=0.864), creatinine (r-value=0.882) on third day. Also, levels of urinary KIM-1 significantly increased (p<0.001) with the severity of tubular injury.Conclusion: Urinary KIM-1 is a promising quick predictive marker of AKI in contrast to traditional markers,serum urea and creatinine.
机译：急性肾损伤（AKI）是指肾功能的突然损害导致保留含氮废物。急性管状坏死涉及肾小管中上皮衬里的局部坏死。一种可溶形式的人肾损伤分子-1（Kim-1）是一种膜跨越蛋白，其赋予上皮细胞，其在缺血性肾脏后的吞噬细胞和吞噬细胞的能力：估算患者尿kim-1水平随着蛇咬伤作为早期检测AKI的潜在生物标志物。从2014年1月到2014年8月。没有AKI的患者被视为控制权，那些开发AKI的人被视为案件。收集并通过酶联免疫吸附剂测定（ELISA），方法，血清肌酐（通过动力酶 - 谷氨酸脱氢酶方法（通过脲酶 - 谷氨酸脱氢酶方法分析血对尿基-1分析并分析使用学生的T检验，P值<0.05被认为是显着的。 Pearson的相关系数用于评估测量参数之间的相关性。结果：在100名患者中被诊断为患有AKI和56名患者的患者没有发展AKI。在<40岁≥40岁之间的年龄组（P值= 0.39）和对照中，在<40岁和年龄≥40岁之间的尿kim-1值中没有发现显着差异（p值= 0.65）。在开发AKI的蛇咬伤情况下，观察了泌尿金对1的显着高度。发现尿kim-1水平在入院后24小时内显着上升（p值<0.001），而血清肌酐和尿素值未增加，直到肾毒性创伤的第3天。第1天的尿尿布和血清肌酐可忽略不计（R值= 0.093，p值= 0.54）和尿尿基-1和第1天的尿素具有低正相关性（R值= 0.380，P-值= 0.011）。对于肾脏的渐进损害，在第三天尿尿嘧啶和血清尿素（R值= 0.864）之间发现阳性相关性，肌酐（R值= 0.882）。此外，尿kim-1水平显着增加（p <0.001），具有管状损伤的严重程度。结论：尿kim-1是与传统标志物，血清尿素和肌酐相比的Aki的有希望的快速预测标志。

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