...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Cutaneous Melanoma in African Albinos: A Systematic Review
【24h】

Cutaneous Melanoma in African Albinos: A Systematic Review

机译：非洲albinos的皮肤黑素瘤：系统审查

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cutaneous melanoma (CM) is reported rare in African albinos inspite of their non or hypomelanised sun-sensitive skin and inhabitance of high ultravoilet index environment. The precise prevalence of CM has not been established in African albinos.Aim: To highlight the frequency of CM in all histologically confirmed skin cancer lesions in African albinos.Materials and Methods: The search was conducted on 28th May 2020 and updated on 8th September 2020 for systematic review. Five databases- African Journals On Line (AJOL), PubMed, Europe PubMed Central, Google scholar and Cochrane library were systematically searched for relevant articles. Included studies were case reports and cross-sectional studies of histologically confirmed skin cancers in which African albinos were the overall subject of the study or were identified as a sub group in mixed sample with normally pigmented Africans.Results: There were 715 skin cancer lesions presenting in 556 African albino skin cancer patients. Only six CM were identified. Over 80% (22/27) of the reviewed studies reported no case of CM. Out of the six melanomas two were acral lentiginous, two nodular, while the histologic subtype was unspecified in two cases.Conclusion: The frequency of CM amongst histologically confirmed skin cancer lesions in African albinos is extremely low. Given that only a fraction of albinos develops skin cancer, authors extrapolate that prevalence of CM in the general population of African albinos is infinitesimal. Elucidating the processes inhibiting melanomagenesis in African albino could provide targets for melanoma therapy in the wider population.
机译：据报道，非洲敏感性罕见的黑色素瘤（cm）罕见的是它们的非阳光敏感皮肤和高紫外线指数环境的居民。非洲Albinos.aim尚未建立CM的精确普及率：突出非洲Albinos中的所有组织学证实皮肤癌病变的频率.8020年5月28日进行并于2020年9月8日更新用于系统审查。 5个数据库 - 非洲期刊（AJOL），PubMed，欧洲PubMed Central，Google Scholar和Cochrane图书馆得到了系统地搜索了相关文章。包括的研究是病例报告和对组织学证实皮肤癌的横截面研究，其中非洲白化病毒是研究的整体主题，或者被鉴定为混合样品中的亚组，其与通常色素的非洲人。结果：出现715个皮肤癌病变在556名非洲白化皮肤癌症患者中。确定只有六厘米。超过80％（22/27）的审查研究报告说没有厘米。在六个黑色素瘤中，两种是急性熊魂，两种结节，而组织学亚型在两种情况下未指明。结论：非洲白化病毒组织学证实皮肤癌病变的CM频率极低。鉴于只有Albinos的一小部分发展皮肤癌，提交人推断了非洲albinos一般人群中CM的患病率是无穷无尽的。阐明抑制抑制非洲白果瘤的方法可以为更广泛的人群提供黑素瘤治疗的靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号