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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Pathophysiological Determinants ofCardiac Remodelling- A SystematicReview and Meta-analysis
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Pathophysiological Determinants ofCardiac Remodelling- A SystematicReview and Meta-analysis

机译：心脏重塑的病理生理学决定因素 - 一种系统综述与荟萃分析

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Cardiac remodeling is a physiological and pathological condition followed by Myocardial Infarction (MI), valvular dysfunctions and cardiomyopathy. It is associated with cardiac function and structural characteristics. Hence, the remodeling is a therapeutic target following cardiac events.Aim: This review was conducted to determine the risk of morbidity, mortality and structural characteristics related cardiac remodeling.Materials and Methods: PubMed, MEDLINE, EMBASE, and ProQuest, were searched electronically, by using {("Morbiditya€? and "Mortality" and "LV parameters" and "Structural Characteristics") and Cardiac ("Remodeling" and "Regeneration")}. "Mantela€“ Haenszel Odds Ratio", "mean differences", and "95% Confidence Interval (CI)" were computed for meta-analysis.Results: Overall, 425 titles or abstracts were identified from the initial search, of which full manuscripts of 103 studies were retrieved. Out of the 103 studies, 22 were subjected to data extraction and analysis. The risk of mortality was higher among patients with myocardial fibrosis. Metoprolol treated group had a lesser incidence of Postoperative Atrial Fibrillation (PAF). Ejection fraction, end systolic and diastolic volumes were consistent between the medical treatments and Percutaneous Coronary Interventions (PCI) groups.Conclusion: The PCIs are associated with long term survival among the patients with cardiac remodeling.
机译：心脏重塑是一种生理和病理条件，然后是心肌梗塞（MI），瓣膜功能障碍和心肌病。它与心功能和结构特征有关。因此，重塑是心脏事件后的治疗目标。此次审查是为了确定发病率，死亡率和结构特征的风险相关的心脏重塑。材料和方法：被电子方式搜索Pubmed，Medline，Embase和Proquest，通过使用{（“Morbitiona€？和”死亡率“和”LV参数“和”结构特征“）和心脏（”改造“和”再生“）}。”Mantela€“Haenszel赔率比”，“意味着差异”，计算“95％置信区间（CI）”进行Meta分析。结果：总体而言，从初始搜索中确定了425个标题或摘要，其中检索了103项研究的全面稿件。在103项研究中，22项受数据提取和分析。心肌纤维化患者的死亡风险较高。美容治疗组术后心房颤动的发病率较小（PAF）。射血分数，最终收缩量和舒张型体积在医学治疗和经皮冠状动脉干预（PCI）基团之间一致。结论：PCIS与心脏重塑患者的长期存活相关。

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