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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Primary Gastrointestinal Lymphomas in Adults: An Institutional Experience of 15 Years from Northern India
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Primary Gastrointestinal Lymphomas in Adults: An Institutional Experience of 15 Years from Northern India

机译：成人原发性胃肠淋巴瘤：来自印度北部15年的机构经验

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Primary Gastrointestinal Lymphomas (PGIL) are uncommon and distinct Gastrointestinal Tract (GIT) malignancies which vary in their epidemiologic and clinicopathologic features worldwide. Since gastrointestinal malignancies are commonest malignancies in Kashmir valley, we intended to study PGIL in our hospital set up.Aim: To study the clinicopathological and demographic profile of PGILMaterials and Methods: This combined retrospective (eight and a half years) and prospective (six and a half years) descriptive observational study of 15 years was performed at Sher-i-Kashmir Institute of Medical Sciences, Srinagar from April 1998 to March 2013. Total 93 cases were included as per Dawson’s criteria. All the cases were reviewed and reclassified according to the World Health Organisation (WHO)- Revised European American Classification of Lymphoid Neoplasms (REAL). Statistical analysis was done using Graph Pad Prism 8.Results: Ninety-three patients (Male: Female ratio, 3:1) with a mean age of 47 years (age range; 18-70 years) were studied. Patients mostly presented with non specific symptoms like abdominal pain (n=79) and anorexia (n=45); and small intestine (n=30), stomach (n=27) and large intestine (n=26) were the major sites affected. Histopathological and Immunohistochemical (IHC) studies revealed most of them to be Non Hodgkin’s Lymphoma (NHL) of B-cell type (n=89) with Diffuse Large B-Cell Lymphoma (DLBCL), the commonest subtype (n=66) followed by Mucosa Associated Lymphoid Tissue (MALT) lymphoma (n=21). Stage distribution included 64 stage IE, 27 stage IIE and 2 stage IIIE patients. Surgical resection was performed in 53 patients along with chemotherapy (25), chemoradiotherapy (20) and anti-Helicobacter pylori (anti-H. pylori) treatment (2). Forty patients received chemotherapy without surgery, along with anti-H.pylori treatment (14) and radiotherapy (7). Mean survival of patients was 42 months.Conclusion: Primary Gastrointestinal Lymphomas (PGIL), although uncommon GIT malignancy, can clinically mimic any GIT disease and can involve any part of GIT. A high degree of suspicion can pick up these lymphomas early and a judicial combination of surgery, chemotherapy and radiotherapy can be offered for better survival. Further, IHC studies including genetic and molecular studies along with long term follow-up studies, are required to have a better understanding of these lymphomas in our region.
机译：原发性胃肠淋巴瘤（PGIL）是罕见和不同的胃肠道（Git）恶性肿瘤，其在全球其流行病学和临床病理学特征中变化。由于胃肠道恶性肿瘤是克什米尔山谷中最常见的恶性肿瘤，我们打算在我们的医院设定的PGIN学习：研究PGIL材料和方法的临床病理和人口统计概况：这一结合的回顾（八年半）和预期（六年半）半年来）对15年来的描述性观察研究是在1998年4月至2013年3月的SRINAGAR Sher-i-Kashmir医学研究所进行了15年。根据道森的标准，共有93例案件。所有案件根据世界卫生组织（WHO） - 修订的欧洲美国淋巴瘤分类（REAL）进行了审查和重新分类。使用曲线垫棱镜进行统计分析8.结果：九十三名患者（男性：女性比例，3：1），平均年龄为47岁（年龄范围; 18-70岁）。患者主要呈现腹痛（n = 79）和厌食（n = 45）等非特异性症状;小肠（n = 30），胃（n = 27）和大肠（n = 26）是受影响的主要部位。组织病理学和免疫组织化学（IHC）研究表明，大多数是非霍奇金淋巴瘤（NHL）的B细胞类型（n = 89），弥漫性大B细胞淋巴瘤（DLBCL），最常见的亚型（n = 66），然后是粘膜相关淋巴组织（麦芽）淋巴瘤（n = 21）。阶段分布包括64阶段，即27阶段IIE和2阶段IIIE患者。手术切除在53名患者中进行，以及化疗（25），化学疗法（20）和抗螺旋杆菌（抗H.幽门螺杆菌）处理（2）。四十名患者在没有手术的情况下接受化疗，以及抗H.Pylori治疗（14）和放射治疗（7）。患者的平均存活率为42个月。结论：原发性胃肠淋巴瘤（PGIL），虽然罕见的GIT恶性肿瘤，可以临床上模仿任何GIT疾病，可以涉及任何部分Git。高度的怀疑可以早期拿起这些淋巴瘤，可以提高手术，化疗和放射治疗的司法组合，以便更好地生存。此外，IHC研究包括遗传和分子研究以及长期的后续研究，需要更好地了解我们区域的这些淋巴瘤。

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