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首页> 外文期刊>BMC Medical Genomics >Mediation role of body fat distribution (FD) on the relationship between CAV1 rs3807992 polymorphism and metabolic syndrome in overweight and obese women
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Mediation role of body fat distribution (FD) on the relationship between CAV1 rs3807992 polymorphism and metabolic syndrome in overweight and obese women

机译：体脂分布的调解作用（FD）对超重和肥胖女性多态性与代谢综合征关系的关系

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Metabolic syndrome (MetS) is associated with an increased risk of morbidity and mortality in almost all chronic diseases. The most frequent methods for the calculation of a continuous MetS (cMetS) score have used the standardized residuals in linear regression (z-score). Recently, emerging data suggest that one of the main genetic targets is the CAV1, which plays a crucial role in regulating body fat distribution. This study is designed to investigate the relationship between CAV1 rs3807992 genotypes and cMetS, and to determine whether body fat distribution plays a mediating role in this regard. The current cross-sectional study was conducted on 386 overweight and obese females. The CAV1 rs3807992 and body composition were measured by the PCR–RFLP method and bioelectrical impedance analysis, respectively. Serum profile of HDL-C, TGs, FPG, and Insulin were measured by standard protocols. GG allele carriers had significantly lowered Z-MAP (p?=?0.02), total cMetS (p?=?0.03) and higher Z-HDL (p?=?0.001) compared with (A) allele carriers. There was a significant specific indirect effect (standardized coefficient?=?0.19; 95% CI 0.01–0.4) of Visceral fat level (VFL). Although, total body fat was significantly associated with CAV1 rs3807992 and cMetS, the specific indirect effect was not significant (standardized coefficient?=?0.21; 95% CI ??0.006, 0.44). VFL contributed to significant indirect effects of 35% on the relationship between CAV1 and cMetS. Higher visceral adipose tissue may affect the relationship between CAV1 and cMetS. Although CAV1 rs3807992 is linked to VFL in our study, the influence of this polymorphism on MetS is not via total fat.
机译：代谢综合征（METS）与几乎所有慢性疾病的发病率和死亡率增加有关。计算连续METS（CMETS）评分的最常见方法使用了线性回归（Z分数）中的标准化残差。最近，新兴数据表明，其中一个主要的遗传目标是CAV1，它在调节体脂分布方面发挥着至关重要的作用。本研究旨在研究CAV1 RS3807992基因型和CMET之间的关系，并确定体脂分布是否在这方面发挥了调解作用。目前的横截面研究是在386个超重和肥胖的女性上进行的。通过PCR-RFLP方法和生物电阻抗分析测量CAV1 RS3807992和主体组成。通过标准方案测量HDL-C，TGS，FPG和胰岛素的血清曲线。与（a）等位基因载体相比，GG等位基因载体均显着降低Z-MAP（P？= 0.02），总CMET（P？= 0.03）和更高的Z-HDL（P？= 0.001）。有显着的特异性间接效应（标准化系数？=Δ0.19; 95％CI 0.01-0.4），内心脂肪水平（VFL）。虽然，总体脂肪与CAV1 RS3807992和CMET有显着相关，但具体的间接效果不显着（标准化系数？= 0.21; 95％CI？0.006,0.44）。 VFL导致CAV1和CMET之间的关系的显着间接影响为35％。较高的内脏脂肪组织可能影响Cav1和CMET之间的关系。虽然CAV1 RS3807992与我们的研究相关联，但在我们的研究中，这种多态性对Mets的影响不是通过总脂肪。

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