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首页> 外文期刊>Indian Journal of Critical Care Medicine >Hypovitaminosis D and Parathyroid Hormone Response in Critically Ill Children with Sepsis: A Case-control Study
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Hypovitaminosis D and Parathyroid Hormone Response in Critically Ill Children with Sepsis: A Case-control Study

机译：患有败血症的批评性儿童的下钙胺素D和甲状旁腺激素反应：一个案例对照研究

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Background: Critically ill Indian children have a higher prevalence of vitamin D deficiency. However, there is not much data available on the subgroup with sepsis. It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults. Hence, we also sought to analyze the PTH response to vitamin D among the subgroup of critically ill children with sepsis. Patients and methods: Vitamin D and PTH levels of 84 critically ill children with sepsis (cases) and 84 controls were compared between November 2018 and February 2020. Hypovitaminosis D was defined as levels 30 ng/mL. Results: The median (IQR) of vitamin D for cases was 26 (21.30–29.95) ng/mL and that for controls 39.3 (33.65–50.2) ng/mL; p 0.001. Cases had a higher prevalence of hypovitaminosis D as compared to controls (79.7 vs 9.5%; p 0.001). Among the cases, mortality was 24.6% in the 65 children with hypovitaminosis D and 10.5% in those with sufficient vitamin D; the differences were not statistically significant (p = 0.339). There were no significant differences in the duration of pediatric intensive care unit (PICU) stay, serum calcium, PTH, and disease severity among the aforementioned groups. Out of the 65 children with hypovitaminosis D, only 9 (13.8%) were PTH responders. There were no statistically significant differences in mortality, the PICU stay, or disease severity at admission between PTH responders and nonresponders. Conclusions: Hypovitaminosis D was more prevalent among critically ill children with sepsis compared to controls. Parathyroid gland response to hypovitaminosis D was impaired in children with sepsis.
机译：背景：危重印度儿童对维生素D缺乏率较高。但是，在子组上没有败血症的数据没有太多的数据。据报道，甲状旁腺激素（PTH）对批评性儿童和成人的维生素D缺乏症存在受损。因此，我们还试图分析对患有败血症的批评性儿童的亚组中对维生素D的第PH响应。患者和方法：2018年11月和2月20日期间，比较了败血症（病例）和84个控制的维生素D和Pth水平84例患有脓毒症（病例）和84个对照的儿童。下钙胺素D定义为水平＆ 30ng / ml。结果：案件的维生素D中位数（IQR）为26（21.30-29.95）Ng / ml，对照组39.3（33.65-50.2）Ng / ml; P＆ 0.001。与对照相比，病例具有更高的下钙氨基酶D次数（79.7 Vs.9.5％; P <0.001）。其中65例含有低维生素D.10.5％的65名儿童死亡率为24.6％;差异没有统计学意义（p = 0.339）。儿科重症监护单元（PICU）停留，血清钙，PTH和疾病严重程度没有显着差异。在65名患有低血清胺源性D的儿童中，只有9（13.8％）是PTH响应者。在PTH响应者和无反应者之间的入学中，死亡率，PICU住宿或疾病严重程度没有统计学上显着差异。结论：与对照相比，脓毒症的严重生病儿童中，低温氨酰胺DINOSION病症。对患有败血症的儿童受到抑制症对低血清胺的腺体反应。

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