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首页> 外文期刊>Indian Journal of Critical Care Medicine >Severe Acute Respiratory Infection Surveillance during the Initial Phase of the COVID-19 Outbreak in North India: A Comparison of COVID-19 to Other SARI Causes
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Severe Acute Respiratory Infection Surveillance during the Initial Phase of the COVID-19 Outbreak in North India: A Comparison of COVID-19 to Other SARI Causes

机译：北印度Covid-19爆发的初始阶段的严重急性呼吸道感染监测：Covid-19对其他SARI的比较

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Introduction:World Health Organization proposes severe acute respiratory infection (SARI) case definition for coronavirus disease 2019 (COVID-19) surveillance; however, early differentiation between SARI etiologies remains challenging. We aimed to investigate the spectrum and outcome of SARI and compare COVID-19 to non-COVID-19 causes.Patients and methods:A prospective cohort study was conducted between March 15, 2020, to August 15, 2020, at an adult medical emergency in North India. SARI was diagnosed using a "modified" case definition-febrile respiratory symptoms or radiographic evidence of pneumonia or acute respiratory distress syndrome of ≤14 days duration, along with a need for hospitalization and in the absence of an alternative etiology that fully explains the illness. COVID-19 was diagnosed with reverse transcription-polymerase chain reaction testing.Results:In total, 95/212 (44.8%) cases had COVID-19. Community-acquired pneumonia (n = 57), exacerbation of chronic lung disease (n = 11), heart failure (n = 11), tropical febrile illnesses (n = 10), and influenza A (n = 5) were common non-COVID-19 causes. No between-group differences were apparent in age ≥60 years, comorbidities, oxygenation, leukocytosis, lymphopenia, acute physiology and chronic health evaluation (APACHE)-II score, CURB-65 score, and ventilator requirement at 24-hour. Bilateral lung distribution and middle-lower zones involvement in radiography predicted COVID-19. The median hospital stay was longer with COVID-19 (12 versus 5 days, p = 0.000); however, mortality was similar (31.6% versus 28.2%, p = 0.593). Independent mortality predictors were higher mean APACHE II in COVID-19 and early ventilator requirement in non-COVID-19 cases.Conclusions:COVID-19 has similar severity and mortality as non-COVID-19 SARI but requires an extended hospital stay. Including radiography in the SARI definition might improve COVID-19 surveillance.How to cite this article:Pannu AK, Kumar M, Singh P, Shaji A, Ghosh A, Behera A, et al. Severe Acute Respiratory Infection Surveillance during the Initial Phase of the COVID-19 Outbreak in North India: A Comparison of COVID-19 to Other SARI Causes. Indian J Crit Care Med 2021;25(7):761-767.Copyright ? 2021; Jaypee Brothers Medical Publishers (P) Ltd.
机译：简介：世界卫生组织提出严重的急性呼吸道感染（SARI）案例定义2019（Covid-19）监测;然而，Sari病因之间的早期分化仍然挑战。我们的旨在调查莎丽的频谱和结果，并比较Covid-19对非Covid-19的原因.Patient和方法：在成人医疗紧急情况下，2020年3月15日至2020年3月15日至2020年3月15日之间进行了预期队列研究在印度北部。莎丽被诊断为使用“修饰的”病例定义 - 发热呼吸症状或肺炎或急性呼吸窘迫综合征≤14天持续时间的射线照相证据，以及需要住院和没有完全解释疾病的替代病因。 Covid-19被诊断为逆转录 - 聚合酶链反应测试。结果：总共95/212（44.8％）病例有Covid-19。患有社区肺炎（n = 57），加剧慢性肺病（n = 11），心力衰竭（n = 11），热带发热疾病（n = 10），流感a（n = 5）是常见的非Covid-19原因。在≥60岁之间，组合，氧合，白细胞增多率，淋巴细胞，急性生理学和慢性健康评估（Apache）-II评分，Curb-65评分和呼吸机要求在24小时时进行淋巴单抗，急性生理学和慢性健康评估。双侧肺部分布和中下区域参与射线照相预测的Covid-19。 Covid-19（12与5天，P = 0.000），中位医院住宿时间更长然而，死亡率相似（31.6％对28.2％，p = 0.593）。独立的死亡率预测因子在Covid-19和早期呼吸机需求中均为高平均Apache II，在非Covid-19案件中的早期呼吸机需求。结论：Covid-19具有类似的严重程度和死亡率，作为非Covid-19 Sari，但需要延长住院住院。在Sari定义中包括放射线照相可能会改善Covid-19监视。如何引用本文：Pannu Ak，Kumar M，Singh P，Shaji A，Ghosh A，Behera A等。北印度Covid-19爆发的初始阶段严重急性呼吸道感染监测：Covid-19对其他SARI的比较。印度j crit care med 2021; 25（7）：761-767.copyright？ 2021; Jaypee Brothers Medical Publishers（P）有限公司

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