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首页> 外文期刊>Indian Journal of Critical Care Medicine >Effect of Change in Body Weight on Clinical Outcomes in Critically Ill Patients
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Effect of Change in Body Weight on Clinical Outcomes in Critically Ill Patients

机译：体重变化对危重病患者临床结果的影响

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Background: Intravenous fluid optimization is an essential component of managing patients in a critical care setting. A cumulative positive fluid balance is consistent with poor outcomes in patients admitted to the intensive care unit (ICU). The overall utility of net cumulative fluid balance as a surrogate for assessing fluid overload has been interrogated. Materials and methods: This study was a prospective single-center observational study, which was done to correlate body weight changes with fluid balance in ICU patients and evaluate its impact on clinical outcomes. Inclusion criteria consisted of adult patients who were admitted to the critical care unit on specialized beds with integrated weighing scales between September 2017 and December 2018. The evaluation of the effect of changes in body weight on ICU survival was the primary objective of the study. Results: We enrolled 105 patients in this study. The ICU mortality was 23.80% with non-survivors showing more weight gain than the survivors. Statistically significant weight gain was documented in the non-survivors on days 3 and 4 (1.9 vs 1.05; p = 0.0084 and 2.6 vs 1.6; p = 0.0030) of ICU admission. Non-survivors had greater cumulative positive fluid balance on fourth, fifth, and sixth days post-ICU admission when compared to survivors (3586 vs 1659 mL, p= 0.0322; 5418 vs 1255 mL, p= 0.0017; and 5430 vs 2305 mL p= 0.0264, respectively). In multivariate regression analysis, cumulative fluid balance did not correlate with days on mechanical ventilation or length of stay in ICU. Changes in body weight and cumulative fluid balance showed a good correlation. Conclusion: In patients admitted to the ICU, weight gain on third and fourth days of admission is concordant with increased ICU mortality. Body weight changes were seen to correlate well with the cumulative fluid balance.
机译：背景：静脉内流体优化是在关键护理环境中管理患者的重要组成部分。累积的正液平衡与入院的患者的差异不良，达到重症监护病房（ICU）。媒体累积流体平衡作为评估流体过载的替代品的整体效用已经被询问。材料和方法：本研究是一项前瞻性单中心观察研究，这是为了与ICU患者的流体平衡相关，并评估其对临床结果的影响。纳入标准由成年患者组成，该患者于2017年9月至2018年9月之间录取了专业床的主要护理单位。对ICU生存的体重变化的评估是该研究的主要目标。结果：我们在本研究中注册了105名患者。 ICU死亡率为23.80％，非幸存者显示比幸存者更多的体重增加。在第3天和第4天（1.9 Vs 1.05; P = 0.0084和2.6 Vs 1.6; P = 0.0030）的非幸存者中记录了统计学上的重量增益。与幸存者相比，ICU后第四个，第五个和第六天具有更大的累积阳性液体平衡（3586 Vs 1659ml，p = 0.0322; 5418 Vs 1255ml，p = 0.0017;和5430 Vs 2305 ml p = 0.0264分别）。在多变量回归分析中，累积流体平衡与ICU的机械通风或逗留时间的天数无关。体重和累积液平衡的变化显示出良好的相关性。结论：在入院患者的患者中，加入第三和第四天的体重增加与ICU死亡率增加。观察到体重变化与累积液平衡均匀相关。

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