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首页> 外文期刊>Frontiers in Neuropharmacology >Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule
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Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule

机译：在为期三周治疗时间表期间，在三周治疗时间表中提高重复电针对嘌呤和酸性疼痛的效率

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摘要

Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world. We studied in rats the efficiency of electroacupuncture (EAP) applied to the Zusanli acupoint (ST36) as an analgesic treatment over a 3-week period of time on purine (α,β-methylene ATP, dibenzoyl-ATP)- and acid (pH 6.0 medium)-induced pain in the rat paw. The two ATP derivatives stimulated P2X3 and P2X7 receptors, respectively, while the slightly acidic medium stimulated the “acid-sensitive ion channel 3” (ASIC3). It was found that the P2X7 receptor and ASIC-mediated pain was counteracted by EAP with greater efficiency at the end than at the beginning of the treatment schedule, while the P2X3 receptor–mediated pain was not. Our findings have important clinical and theoretical consequences, among others, because they are difficult to reconcile with the assumption that AP is primarily due to the release of peripheral and central opioid peptides causing the well-known tolerance to their effects. In consequence, AP is a convenient therapeutic instrument to treat subacute and chronic pain.
机译：针灸（AP）是中医药治疗曲目的重要组成部分，已被广泛用于缓解世界各地的慢性痛苦条件。我们研究大鼠施用到Zusanli穴位（ST36）的电针（EAP）的效率，作为嘌呤（α，β-亚甲基ATP，二苯甲酰基） - 和酸（pH）的3周的时间（α），pH值6.0培养基）诱导老鼠爪子的疼痛。两种ATP衍生物分别刺激P2X3和P2X7受体，而微酸性介质刺激“酸敏感离子通道3”（ASIC3）。发现P2X7受体和ASIC介导的疼痛通过EAP抵消，效率更高，而不是在治疗时间表开始时，而P2X3受体介导的疼痛则不是。我们的研究结果具有重要的临床和理论后果等，因为它们难以使AP主要是由于外周和中枢阿片类药物释放导致众所周知的耐受性的缺陷。结果，AP是一种治疗亚急性和慢性疼痛的方便治疗仪器。

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