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Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review

机译：肺动脉高压和慢性血栓栓塞肺动脉高压的流行病学：系统文献综述最准确估算的鉴定

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This systematic review of literature and online reports critically appraised incidence and prevalence estimates of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension to identify the most accurate estimates. MedlineVR and EmbaseVR databases were searched for articles published between 1 January 2003 and 31 August 2020. Studies were grouped according to whether they were registries (population-based estimates), clinical databases (hospital-based estimates) or claims/ administrative databases. Registries were classified into systematic and non-systematic registries, according to whether every national centre participated. Of 7309 publications identified, 5414 were screened after removal of duplicates and 33 were included. Inclusion was based on study type, availability of a clear numerator (diagnosed population) and a population- or hospital-based denominator, or all primary data required to calculate estimates. Only the most recent publication from a database was included. Most studies were based on European data and very few included children. In adults, the range of estimates per million was approximately 20-fold for pulmonary arterial hypertension incidence (1.5–32) and prevalence (12.4–268) and of similar magnitude for chronic thromboembolic pulmonary hypertension incidence (0.9–39) and prevalence (14.5–144). Recent (5 years) national systematic registry data from centralised healthcare systems provided the following ranges in adult estimates per million: approximately 5.8 for pulmonary arterial hypertension incidence, 47.6–54.7 for pulmonary arterial hypertension prevalence, 3.1–6.0 for chronic thromboembolic pulmonary hypertension incidence and 25.8–38.4 for chronic thromboembolic pulmonary hypertension prevalence. These estimates were considered the most reliable and consistent for the scientific community to plan for resource allocation and improve detection rates.
机译：这种文献和在线报告的系统审查严重评估了肺动脉高压和慢性血栓栓塞肺动脉高压的发病率和患病率估计，以确定最准确的估计。搜索MEDINEVR和EMBASEVR数据库于2003年1月1日至2020年8月31日发表的文章。根据他们是否是注册管理机构（基于人口的估计数），临床数据库（基于医院的估计数）或索赔/行政数据库的研究进行了分组。根据每个国家中心是否参与，注册管理机构被分类为系统和非系统的注册管理机构。鉴定了7309个出版物，在去除重复后，筛选了5414个，包括33个。包含基于研究类型，清除分子（诊断群体）和基于人口或医院的分母的可用性，或计算估计所需的所有主要数据。仅包含来自数据库的最新发布。大多数研究基于欧洲数据，并且很少包括儿童。在成人中，百百万估计范围约为肺动脉高血压发病率（1.5-32）和患病率（12.4-268）和慢性血栓栓塞肺动脉高血压发病率（0.9-39）和患病率相似的（14.5 -144）。最近（＆＃x1; 5年）来自集中医疗保健系统的国家系统注册表数据在成人估算中提供了以下范围：肺动脉高血压发病率约为5.8，用于肺动脉高压患病率，3.1-6.0用于慢性血栓栓塞3.1-6.0肺动脉高压发病率和25.8-38.4慢性血栓栓塞肺动脉高压患病率。这些估计被认为是科学界最可靠和最持态度，以便为资源分配计划并提高检测率。

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