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Electronic Nicotine Delivery Systems and Serum Folate: A Case Study

机译：电子尼古丁递送系统和血清叶酸：一个案例研究

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Introduction: In 2018, the US Surgeon General declared youth electronic nicotine delivery systems (ENDS) use as an epidemic. Combustible cigarettes have been shown to adversely affect folate status; however, no study to date has explored how ENDS impact folate status. Methods: In this case study, a white 18-year-old woman was followed for a 1-month period as part of a larger study. During her participation in the study, a self-report of dietary folate consumption and use of alcohol, tobacco, and other drugs (ATOD) was collected. Each week, dried blood spots were collected to assess red blood cell (RBC) and serum folate. Results: During the first 2weeks of the study, she used ENDS and her serum folate values were depleted in the ranges of 1.91 to 4.39 μg/L. During the third week, when no ENDS were used, her serum folate value was measured at 29.44 μg/L. When ENDS use resumed during the fourth week, her serum folate value fell to 7.50 μg/L. Conclusions: This relationship suggests the need for additional studies on ENDS use and serum folate status, particularly among adolescent women who already have the lowest folate status nationally.
机译：介绍：2018年，美国外科医生宣布青年电子尼古丁交付系统（末端）用作流行病。可燃卷烟已被证明对叶酸地位产生不利影响;但是，迄今尚未研究过，探索了如何影响叶柄状况。方法：在这种情况下，作为更大研究的一部分，随后是一个白人18岁的女性。在参加研究期间，收集了膳食叶酸消耗和使用酒精，烟草和其他药物（Atod）的自我报告。每周，收集干血斑以评估红细胞（RBC）和血清叶酸。结果：在研究的前2周，她使用的末端，她的血清叶酸值耗尽1.91至4.39μg/升。在第三周，当使用任何末端时，她的血清叶酸值在29.44μg/ L中测量。当结束在第四周恢复时，她的血清叶酸值落到7.50μg/升。结论：这种关系表明，需要额外的研究结束使用和血清叶酸地位，特别是在已经全国性最低的叶鹿状态的青少年女性中。

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