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首页> 外文期刊>Journal of experimental & clinical cancer research : >Statins: a repurposed drug to fight cancer
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Statins: a repurposed drug to fight cancer

机译：他汀类药物：一种重新培育的药物来对抗癌症

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As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties of statins have attracted much attention and indicated the potential of statins as repurposed drugs for the treatment of cancer. A large number of clinical and epidemiological studies have described the anticancer properties of statins, but the evidence for anticancer effectiveness of statins is inconsistent. It may be that certain molecular subtypes of cancer are more vulnerable to statin therapy than others. Whether statins have clinical anticancer effects is still an active area of research. Statins appear to enhance the efficacy and address the shortcomings associated with conventional cancer treatments, suggesting that statins should be considered in the context of combined therapies for cancer. Here, we present a comprehensive review of the potential of statins in anti-cancer treatments. We discuss the current understanding of the mechanisms underlying the anti-cancer properties of statins and their effects on different malignancies. We also provide recommendations for the design of future well-designed clinical trials of the anti-cancer efficacy of statins.
机译：作为竞争性HMG-CoA还原酶（HMGCR）抑制剂，他汀类药物不仅可以减少胆固醇并提高心血管风险，而且还表现出与其脂质降低效果无关的脂肪效应。其中，他汀类药物的抗癌性质引起了许多关注，并表明他汀类药物作为用于治疗癌症的可被重新培育的药物。大量临床和流行病学研究描述了他汀类药物的抗癌特性，但抗癌患者的抗癌效果的证据是不一致的。可能是某些癌症的分子亚型比其他癌症更容易受到他汀类药物的影响。他汀类药物是否具有临床抗癌效果仍是一个活跃的研究领域。他汀类药物似乎增强了患有常规癌症治疗相关的疗效和解决缺点，这表明他汀类药物应在癌症组合治疗的情况下考虑。在这里，我们对抗癌治疗中的潜力进行了全面的审查。我们讨论目前对抗癌特性的机制的理解及其对不同恶性肿瘤的影响。我们还提供了建议，为未来设计精心设计的抗癌疗效的临床试验的建议。

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