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首页> 外文期刊>British Journal of Cancer >Mendelian randomisation study of smoking exposure in relation to breast cancer risk
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Mendelian randomisation study of smoking exposure in relation to breast cancer risk

机译：孟德利安随机化吸烟曝光与乳腺癌风险有关的随机研究

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Background Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P ?=?0.11?×?10 ~(–2)), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P ?=?0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
机译：背景，尽管烟草吸烟和乳腺癌风险之间的巨大关联，但近期流行病学研究仍然是烟草仍然有关与乳腺癌风险有关的常见。方法应用孟德尔随机化（MR）来评估吸烟对乳腺癌风险的潜在因果效果。在全基因组吸烟指数（LSI）或每天香烟（CPD）的基因组 - 宽协会（LSI）或香烟（CPD）中报告的单个级别数据以及164个单核苷酸多态性（SNP）的总结统计数据均用于获得MR效应估计。 108,420侵袭性乳腺癌病例和87,681种对照的数据用于LSI分析，并在患有26,147例癌症病例和26,072个对照中进行的患者进行的CPD分析。进行敏感性分析以解决Pleiotropy。结果遗传预测的LSI与乳腺癌风险增加有关（或1.18每SD，95％CI：1.07-1.30，P？=？0.11？×10〜（ - 2）），但没有任何转基因的证据预测CPD（或1.02,95％CI：0.78-1.19，P？= 0.85）。敏感性分析产生了类似的结果，并且没有出现强大的脂肪效应证据。结论我们的MR研究提供了潜在的因果关系与乳腺癌风险的潜在因果关系，为终身吸烟曝光而不是每天吸烟者的卷烟。

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