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Procoagulant activity of extracellular vesicles in plasma of patients with SARS-CoV-2 infection

机译:SARS-COV-2感染患者血浆细胞外囊泡的促进剂活性

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Extracellular vesicles (EVs) have been of special interest in recent years. Emerging evidence suggests that EVs play a key role in health and disease [1]. Released by all cell types, EVs circulate freely, are present in all body fluids and mediate intercellular communication locally and systemically. Further, EVs reprogram functions of circulating and tissue-bound recipient cells in physiological and pathological conditions [2]. EVs represent a heterogenous population of differently sized nanovesicles with distinct biogenesis that carry diverse molecular and genetic cargo and deliver it to recipient cells [1,2]. Numbers of circulating EVs increase in inflammatory or infectious diseases, and their molecular/genetic content changes with disease progression. Therefore, EVs are being intensively evaluated as noninvasive liquid biomarkers of disease onset, progression and/or outcome [3].
机译:近年来,细胞外囊(EVS)对特别感兴趣。 新兴的证据表明,EVS在健康和疾病中发挥着关键作用[1]。 通过所有细胞类型释放,EVS自由循环,存在于所有体液中,并在本地和系统性地介导细胞间通信。 此外,EVS在生理和病理条件下的循环和组织接受者细胞的重新编程功能[2]。 EVS代表了具有不同生物发生的不同大小的纳米粒子的异质群,携带各种分子和遗传货物,并将其递送给受体细胞[1,2]。 血液循环的循环循环或传染病的数量,以及它们的分子/遗传含量随疾病进展而变化。 因此,EVS正在集中评估为疾病发病,进展和/或结果的非侵入性液体生物标志物[3]。

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