首页> 中文期刊> 《世界临床病例杂志》 >Regulatory roles of extracellular vesicles in immune responses against Mycobacterium tuberculosis infection

Regulatory roles of extracellular vesicles in immune responses against Mycobacterium tuberculosis infection

         

摘要

Extracellular vesicles(EVs)are cystic vesicles naturally released by most mammalian cells and bacteria.EV contents include proteins,lipids,and nucleic acids.EVs can act as messengers to transmit a variety of molecules to recipient cells and thus play important regulatory roles in intercellular signal transduction.EVs,released by either a host cell or a pathogen,can carry pathogen-associated antigens and thus act as modulators of immune responses.EVs derived from Mycobacterium tuberculosis(Mtb)-infected cells can regulate the innate immune response through various pathways,such as regulating the release of inflammatory cytokines.In addition,EVs can mediate antigen presentation and regulate the adaptive immune response by transmitting immunoregulatory molecules to T helper cells.In this review,we summarize the regulatory roles of EVs in the immune response against Mtb.

著录项

  • 来源
    《世界临床病例杂志》 |2021年第25期|P.7311-7318|共8页
  • 作者单位

    Department of Laboratory Medicine the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region ChinaDepartment of Parasitology the College of Basic Medical Sciences of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region China;

    Department of Laboratory Medicine the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region ChinaDepartment of Parasitology the College of Basic Medical Sciences of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region China;

    Department of Parasitology the College of Basic Medical Sciences of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region China;

    Department of Laboratory Medicine the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region China;

    Department of Laboratory Medicine the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region ChinaDepartment of Parasitology the College of Basic Medical Sciences of Inner Mongolia Medical University Hohhot 010050 Inner Mongolia Autonomous Region China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 消化系及腹部疾病;
  • 关键词

    Extracellular vesicles; Exosomes; Mycobacterium tuberculosis; Infection; Antigen; Immune regulation;

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