• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JMIR public health and surveillance. >How to evaluate a schedule for SARS-CoV-2 swab test timing: a mixed model approach to study how probability of SARS-CoV-2 positivity changes over time
【24h】

How to evaluate a schedule for SARS-CoV-2 swab test timing: a mixed model approach to study how probability of SARS-CoV-2 positivity changes over time

机译：如何评估SARS-COV-2拭子测试时序的时间表：研究SARS-COV-2积极性随时间变化的概率如何变化的混合模型方法

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background During the COVID-19 pandemic, swab tests proved to be effective in containing the infection and served as a means for early diagnosis and contact tracing. However, little evidence exists regarding the correct timing for the execution of the swab test, especially for asymptomatic individuals and health care workers. Objective The objective of this study was to analyze changes in the positive findings over time in individual SARS-CoV-2 swab tests during a health surveillance program. Methods The study was conducted with 2071 health care workers at the University Hospital of Verona, with a known date of close contact with a patient with COVID-19, between February 29 and April 17, 2020. The health care workers underwent a health surveillance program with repeated swab tests to track their virological status. A generalized additive mixed model was used to investigate how the probability of a positive test result changes over time since the last known date of close contact, in an overall sample of individuals who tested positive for COVID-19 and in a subset of individuals with an initial negative swab test finding before being proven positive, to assess different surveillance time intervals. Results Among the 2071 health care workers in this study, 191 (9.2%) tested positive for COVID-19, and 103 (54%) were asymptomatic with no differences based on sex or age. Among 49 (25.7%) cases, the initial swab test yielded negative findings after close contact with a patient with COVID-19. Sex, age, symptoms, and the time of sampling were not different between individuals with an initial negative swab test finding and those who initially tested positive after close contact. In the overall sample, the estimated probability of testing positive was 0.74 on day 1 after close contact, which increased to 0.77 between days 5 and 8. In the 3 different scenarios for scheduled repeated testing intervals (3, 5, and 7 days) in the subgroup of individuals with an initially negative swab test finding, the probability peaked on the sixth, ninth and tenth, and 13th and 14th days, respectively. Conclusions Swab tests can initially yield false-negative outcomes. The probability of testing positive increases from day 1, peaking between days 5 and 8 after close contact with a patient with COVID-19. Early testing, especially in this final time window, is recommended together with a health surveillance program scheduled in close intervals.
机译：背景技术在Covid-19大流行期间，证明在含有感染和担任早期诊断和接触跟踪的手段中有效。然而，关于执行拭子测试的正确时序，特别是对于无症状的人和医疗工作者来说，很少存在。目的本研究的目的是在健康监测计划期间分析各个SARS-COV-2棉签试验随着时间的推移的变化。方法该研究在维罗纳大学医院进行了2071家医疗工作者，其中有一个已知的与Covid-19患者在2020年和4月17日之间与Covid-19的患者密切接触。卫生保健工作者接受了健康监测计划重复的棉签测试以跟踪其病毒学状态。广泛的添加剂混合模型用于研究自上次已知的密切联系日期以来，阳性测试结果随时间变化的概率如何变化，在对Covid-19的阳性测试阳性的个体的整体样本中，以及初始负拭子测试发现之前被证明是积极的，评估不同的监控时间间隔。结果这项研究中的2071名医疗工作者之间，191（9.2％）测试了Covid-19的阳性，103（54％）无症状，没有基于性别或年龄的差异。在49例（25.7％）病例中，初始拭子测试在与患者与Covid-19紧密接触后产生的阴性结果。性别，年龄，症状和采样时间与初始负拭子测试发现的个体之间没有差异，并且在密切接触后最初测试正面的人。在整个样本中，在密切接触后第1天测试阳性的估计概率为0.74，这在第5天和8天之间增加到0.77。在3种不同的方案中，预定的重复测试间隔（3,5和7天）具有初始负拭子试验发现的个体亚组，概率分别达到第六，第九和第十和第13天和第13天。结论棉签试验最初可以产生假阴性结果。在与患者与Covid-19密切接触后，在第1天，在第5天和第8天之间进行测试阳性增加的可能性。早期测试，特别是在该最后的时间窗口中，建议将健康监控程序以紧密区间安排。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号