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首页> 外文期刊>Journal of International Medical Research >Follow-up analysis and histopathological study of gastric mucosa in patients with Helicobacter pylori infection
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Follow-up analysis and histopathological study of gastric mucosa in patients with Helicobacter pylori infection

机译：<斜斜末端=“是”患者胃黏膜胃黏膜的后续分析及组织病理学研究>幽门螺杆菌幽门螺杆菌感染

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Objective To investigate the histomorphological characteristics of the gastric mucosa and the prognosis in patients with Helicobacter pylori infection. Methods Progressive damage to the gastric mucosa was examined by immunohistochemistry in 2294 patients with H. pylori infection and follow-up information was analyzed. Results H. pylori initially colonized the mucus layer covered by the gastric mucosa epithelium, then selectively adhered to and destroyed the surface mucus cells causing intra-gastric and extra-gastric lesions. Gastric mucosal damage induced by H. pylori was divided into five stages according to the depth of H. pylori invasion and degree of lesion deterioration: mucilaginous, surface mucocellular, lamina propria lesion, mucosal atrophy, and intraepithelial neoplasia stages. Morphological follow-up analysis revealed no significant difference in 6-month curative effects between stage I and stage II, but significant differences were found between stages II and III, stages III and IV, and between stages IV and stage V, respectively. Conclusions This novel staging strategy may be a valuable tool for diagnosing and predicting the results of gastric mucosal damage induced by H. pylori infection.
机译：目的探讨胃黏膜胃黏膜胃黏膜的组织形态学特征及幽门螺杆菌感染患者的预后。方法采用免疫组织化学在2294例H.幽门螺杆菌患者中检测胃黏膜渐进损伤。结果H. Pylori最初将含有胃粘膜上皮覆盖的粘液层沉积，然后选择性地粘附并破坏了引起胃内胃内和外胃病变的表面粘液细胞。幽门螺杆菌诱导的胃粘膜损伤根据H.幽门螺杆菌的深度和病变劣化程度分为五个阶段：粘膜损坏程度：粘膜，表面粘膜，层胶血管病变，粘膜萎缩和上皮内瘤周期阶段。形态学后续分析显示，II期和第II期之间的6个月疗效没有显着差异，但分别在阶段II和III，阶段III和IV之间以及阶段IV和阶段V之间发现了显着差异。结论这种新颖的分期策略可能是诊断和预测H. Pylori感染诱导的胃粘膜损伤结果的有价值的工具。

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