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首页> 外文期刊>Journal of surgery and medicine. >The association of TNFα -238 G/A gene polymorphism with alopecia areata
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The association of TNFα -238 G/A gene polymorphism with alopecia areata

机译：TNFα-238g / A基因多态性与脱发血糖菌

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Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses. The aim of this study is to evaluate whether there is a relationship between TNFα -238 G/A gene polymorphism and AA in the Turkish population. Methods: In this case-control study, the frequency of TNFα-238 G/A gene polymorphism and its relationship with some clinical parameters of AA patients were investigated. Seventy-eight AA patients and 78 healthy individuals were included in our study. TNFα -238 G/A polymorphism was evaluated by the PCR-RFLP method. Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P0.001). Frequency of genotypes GG and AA in AA patients (53.8 and 6.4%, respectively) were evidently lower compared to the controls (59 and 25.6%, respectively). Individuals with AA genotype had a lower risk of AA disease (odds ratio (OR)=0.27; 95% CI=0.09-0.79; relative risk (RR)=0.65 (0.49-0.86); P=0.013). GA genotype was significantly higher in patients with AA (39.7%) compared to the control group (15.4%) and an increased risk of patchy AA was observed (OR=2.82, 95% CI=1.28-6.21; RR=1.87 (1.11-3.15); P=0.008). Conclusion: These results suggest that the TNFα -238 G/A gene polymorphism is associated with AA and individuals with GA genotype may have an increased risk of AA.
机译：背景/目的：脱发的脱发（AA），其特征在于脱发，是一种炎症自身免疫疾病。肿瘤坏死因子-α（TNFα）是一种有效的促炎细胞因子，其在炎症和免疫应答中具有非常重要的作用。本研究的目的是评估TNFα-238g / A基因多态性和土耳其人群中的AA之间是否存在关系。方法：在这种情况下，研究了TNFα-238g / A基因多态性的频率及其与AA患者一些临床参数的关系。我们的研究中包含七十八八个AA患者和78名健康个体。通过PCR-RFLP方法评价TNFα-238g / a多态性。结果：患者和对照受试者之间的TNFα-238g / A基因型的分布（P <0.001）显着差异。与对照（分别为59和25.6％），AA患者的基因型GG和AA的频率明显降低（分别为59％和25.6％）。具有AA基因型的个体具有较低的AA疾病的风险（差异比（或）= 0.27; 95％CI = 0.09-0.79;相对风险（RR）= 0.65（0.49-0.86）; P = 0.013）。与对照组（15.4％）相比，AA（39.7％）的患者GA基因型显着高，观察到斑块AA的风险增加（或= 2.82,95％CI = 1.28-6.21; RR = 1.87（1.11- 3.15）; p = 0.008）。结论：这些结果表明TNFα-238g / A基因多态性与AA和具有GA基因型的个体有关可能具有增加的AA风险。

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